CONCENTRATIONS OF EPIDERMAL GROWTH-FACTOR IN MOUSE MILK THROUGHOUT LACTATION
CONCENTRATIONS OF EPIDERMAL GROWTH-FACTOR IN MOUSE MILK THROUGHOUT LACTATION
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DOI：
10.1677/joe.0.0960287
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发表时间：
1983-01-01
影响因子：
4
通讯作者：
RICHARDS, RC
中科院分区：
文献类型：
--
作者：
BEARDMORE, JM;RICHARDS, RC
使用放射免疫测定法来测量整个哺乳期小鼠乳汁中表皮生长因子（EGF）的浓度。小鼠乳汁中的EGF含量从出生起就稳定增加，在哺乳第8天达到427μg/l的浓度。这些高水平一直维持到接近断奶，此时值从第17天下降到第22天的130μg/l。在Biogel P10柱上色谱分析的牛奶样品在纯标准EGF被洗脱的点处给出了免疫反应性的主峰。乳汁 EGF 的来源尚不清楚，但在小鼠乳汁中发现的这种肽的高浓度表明它一定在新生儿中发挥作用。
A radioimmunoassay was used to measure the concentration of epidermal growth factor (EGF) in mouse milk throughout lactation. The EGF content of mouse milk increased steadily from birth to a concentration of 427 .mu.g/l at day 8 of lactation. These high levels were maintained until the approach of weaning, when values decreased from day 17 to 130 .mu.g/l at day 22. Milk samples chromatographed on a Biogel P10 column gave a major peak of immunoreactivity at the point at which pure standard EGF was eluted. The origin of milk EGF is unknown, but the high concentrations of this peptide identified in mouse milk suggest that it must play a role in the neonate.