Delta function is required for bristle organ determination and morphogenesis in Drosophila.
Delta function is required for bristle organ determination and morphogenesis in Drosophila.
复制标题
Delta 函数是果蝇刚毛器官确定和形态发生所必需的。
DOI：
10.1006/dbio.1993.1151
复制
发表时间：
1993
影响因子：
2.7
通讯作者：
Muskavitch,MA
中科院分区：
文献类型：
--
作者：
Parks,AL;Muskavitch,MA
Analyses ofDelta(Dl) temperature-sensitive mutants reveal that reductions inDlfunction during metamorphosis ofDrosophila melanogastercan lead to multiplication or loss of bristle organs on the adult notum, depending on the developmental interval during which such mutants are pulsed at restrictive temperature. Site-dependent macrochaeta multiplication or loss results from pulses 0-21 hr after puparium formation (APF). Microchaeta multiplication results from pulses 7-30 hr APF, while microchaeta loss results from pulses 24-47 hr APF. Supernumerary bristle organs that develop inDlmutants consist of the normal complement of trichogen, tormogen, neuron, and thecogen cells, and appear to arise due to the specification of supernumerary bristle first-order precursor (pI) cells within proneural groups in the developing notum. Loss of complete bristle organs inDlmutants is correlated with the differentiation of all four progeny of the pI cell into neurons. We conclude thatDlfunction is required for cellular interactions central to the correct specification of pI cells within proneural groups, as well as for morphogenesis of the bristle organ itself.
