Modulating cortico-striatal and thalamo-cortical functional connectivity with transcranial direct current stimulation
Modulating cortico-striatal and thalamo-cortical functional connectivity with transcranial direct current stimulation
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DOI：
10.1002/hbm.21380
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发表时间：
2012-10-01
影响因子：
4.8
通讯作者：
Nitsche, Michael A.
中科院分区：
文献类型：
--
作者：
Polania, Rafael;Paulus, Walter;Nitsche, Michael A.
经颅直流电刺激（tDCS）是一种非侵入性脑刺激技术，已被证明通过施加弱直流电来改变皮层的兴奋性和活动。除了皮质内效应之外，功能成像和行为研究表明，tdcs还会导致皮质下区域的改变，然而，这种影响的直接证据很少。我们旨在通过对不同纹状体和丘脑区域的种子功能连通性分析来研究tDCS对皮质-皮层下功能网络的影响，以证明tDCS诱导皮质-纹状体-丘脑回路的改变。fMRI静息状态数据集是在双极tDCS休息10分钟之前和之后立即获得的，阳极/阴极放置在左初级运动皮层（M1）上，阴极/阳极放置在对侧额极皮层上。为了控制可能的安慰剂效应，进行了额外的假刺激。左侧丘脑和同侧初级运动皮层（M1）之间的功能耦合在M1上进行阳极刺激后显着增加。此外，左尾状核与顶叶联合皮层之间的功能连通性显著增强。相反，M1上的阴极tDCS减少了左M1和对侧壳核之间的功能耦合。总之，在这项研究中，我们首次表明tDCS调节皮质纹状体和丘脑皮质回路的功能连接。在这里，我们强调了M1上的阳极tDCS能够调节皮质-纹状体-丘脑-皮质功能运动回路的元素。大脑学报，2012,33:24992508。(c) 2011 Wiley期刊公司
Transcranial direct current stimulation (tDCS) is a noninvasive brain stimulation technique that has been shown to alter cortical excitability and activity via application of weak direct currents. Beyond intracortical effects, functional imaging as well as behavioral studies are suggesting additional tDCS-driven alterations of subcortical areas, however, direct evidence for such effects is scarce. We aimed to investigate the impact of tDCS on cortico-subcortical functional networks by seed functional connectivity analysis of different striatal and thalamic regions to prove tDCS-induced alterations of the cortico-striato-thalamic circuit. fMRI resting state data sets were acquired immediately before and after 10 min of bipolar tDCS during rest, with the anode/cathode placed over the left primary motor cortex (M1) and the cathode/anode over the contralateral frontopolar cortex. To control for possible placebo effects, an additional sham stimulation session was carried out. Functional coupling between the left thalamus and the ipsilateral primary motor cortex (M1) significantly increased following anodal stimulation over M1. Additionally, functional connectivity between the left caudate nucleus and parietal association cortices was significantly strengthened. In contrast, cathodal tDCS over M1 decreased functional coupling between left M1 and contralateral putamen. In summary, in this study, we show for the first time that tDCS modulates functional connectivity of cortico-striatal and thalamo-cortical circuits. Here we highlight that anodal tDCS over M1 is capable of modulating elements of the cortico-striato-thalamo-cortical functional motor circuit. Hum Brain Mapp 33:24992508, 2012. (c) 2011 Wiley Periodicals, Inc.