Insulinogenic sucrose+amino acid mixture ingestion immediately after resistance exercise has an anabolic effect on bone compared with non-insulinogenic fructose+amino acid mixture in growing rats.
Insulinogenic sucrose+amino acid mixture ingestion immediately after resistance exercise has an anabolic effect on bone compared with non-insulinogenic fructose+amino acid mixture in growing rats.
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DOI：
10.1016/j.bone.2014.05.002
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发表时间：
2014-08
期刊：
影响因子：
4.1
通讯作者：
T. Notomi;Ikuaki Karasaki;Y. Okazaki;N. Okimoto;Yushi Kato;K. Ohura;M. Noda;Toshitaka Nakamura;Masashige Suzuki
中科院分区：
文献类型：
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作者：
T. Notomi;Ikuaki Karasaki;Y. Okazaki;N. Okimoto;Yushi Kato;K. Ohura;M. Noda;Toshitaka Nakamura;Masashige Suzuki
最大化峰值骨量是预防骨质疏松症的重要因素。阻力运动增加骨量和强度，而营养补充剂对减少骨质流失有有益的影响。我们以前已经表明，蔗糖和氨基酸（AA），这是强烈的胰岛素原，有效地增加肌肉蛋白质合成的组合摄入。为了研究抗阻运动后立即使用糖和AA溶液的效果，我们比较了胰岛素源蔗糖和非胰岛素源果糖与AA溶液结合或不进行抗阻运动。与运动后摄入果糖+ AA相比，抗阻运动后立即摄入蔗糖可增加骨小梁质量和最大压缩负荷。此外，蔗糖+ AA和运动相结合，增加骨小梁形成和减少骨吸收比果糖和运动相结合。运动时摄入蔗糖+ AA可显著提高血清胰岛素水平。在培养实验中，糖+ AA都不影响成骨细胞和破骨细胞的分化。在一项基因表达研究中，抗阻运动后摄入蔗糖+ AA可上调Runx 2表达水平并降低RANKL/OPG比值。这些结果表明，在抗阻运动后立即合并摄入蔗糖和AA溶液通过改变与骨重建相关的基因表达对骨产生合成代谢作用。虽然将我们的骨重建研究结果从动物转化为人类研究具有挑战性，但我们的研究结果表明，糖+ AA摄入的运动可能有助于改善骨骼健康。
Maximizing peak bone mass is an important factor in osteoporosis prevention. Resistance exercise increases bone mass and strength, while nutritional supplements have beneficial effects on bone loss reduction. We have previously shown that the combined intake of sucrose and amino acids (AA), which is strongly insulinogenic, efficiently increased muscle protein synthesis. To investigate the effects of sugar and an AA solution immediately after resistance exercise, we compared insulinogenic sucrose and non-insulinogenic fructose combined with an AA solution with or without resistance exercise. Sucrose intake immediately after resistance exercise increased the trabecular bone mass and compressive maximum load compared with fructose + AA intake after exercise. Additionally, combined sucrose + AA and exercise increased trabecular bone formation and decreased bone resorption more than combined fructose and exercise. Serum insulin levels were greatly increased by sucrose + AA intake with exercise. In culture experiments, neither sugar + AA affected osteoblast and osteoclast differentiation. In a gene expression study, sucrose + AA intake after resistance exercise was shown to upregulate the Runx2 expression level and decrease RANKL/OPG ratio. These results suggest that the combined intake of sucrose and an AA solution immediately after resistance exercise exerts anabolic effects on bone by altering gene expression related to bone remodeling. Although translation of our bone remodeling findings from animal to human studies has been challenging, our findings suggest that exercise with sugar + AA intake may contribute to improved bone health.