The influence of age on mortality and survival in patients undergoing oesophagogastrectomies. A seven-year experience in a tertiary centre
The influence of age on mortality and survival in patients undergoing oesophagogastrectomies. A seven-year experience in a tertiary centre
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DOI：
10.1510/icvts.2009.223826
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发表时间：
2010-07-01
影响因子：
--
通讯作者：
Page, Richard
中科院分区：
文献类型：
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作者：
Elsayed, Hany;Whittle, Ian;Page, Richard
本研究的目的是评价高龄对在一个高容量中心接受食管癌切除术患者的结局和生存率的影响。我们回顾性分析了2001年5月至2008年4月期间326例食管胃切除术（OG）患者的住院生存情况。我们把病人分成两组。A组（n=218）包括年龄小于70岁的患者，而B组（n=108）包括年龄大于或等于70岁的患者。这两个组是可比的。A组的住院死亡率为11/218（5%），而B组的住院死亡率为13/108（12%）。该差异具有统计学显著性（P=0.024）。多因素分析显示，年龄> 70岁（OR = 2.79）、FEV下降（OR=0.13）和合并心脏病（OR=2.53）是影响OG术后住院死亡的危险因素。尽管年龄超过70岁1不能预测生存率（P=0.21），但重要的独立预测因素是年龄增长[风险比（HR）= 1.03]和疾病分期（HR=1.84）。P值分别为0.0278和0.018。年龄增长是食管切除术后死亡率和生存率的重要危险因素。如果与术前心脏或呼吸系统疾病相关，则死亡率特别高。(C)2010年由欧洲胸外科协会出版。All rights reserved.
The aim of this study was to evaluate the effects of advanced age on the outcome and survival of patients undergoing oesophagectomy for oesophageal cancer at a single high-volume centre. We retrospectively reviewed the hospital survival of 326 patients in oesophagogastrectomies (OGs) in a period from May 2001 to April 2008. We divided the patients into two groups. Group A (n=218) consisted of patients younger than 70 years of age, while Group B (n=108) consisted of patients 70 years of age or older. The two groups were comparable. Inhospital mortality for Group A was 11 out of 218 (5%), while in-hospital mortality for Group B was 13 out of 108 (12%). This difference was statistically significant (P=0.024). Multivariate analysis showed that risk factors for in-hospital mortality after OG included age over 70 years wodds ratio (OR) = 2.79], reduced % of predicted FEV (OR=0.13) and cardiac co-morbidity (OR=2.53). Despite age over 70 years 1 proving not to be predictive of survival (P=0.21), significant independent predictors were advancing age [hazard ratio (HR) = 1.03] and stage of disease (HR=1.84). P-values were 0.0278 and 0.018, respectively. Increasing age is a significant risk factor for mortality and survival after oesophageal resection operations. This mortality is particularly high if associated with a preoperative cardiac or respiratory morbidity. (C) 2010 Published by European Association for Cardio-Thoracic Surgery. All rights reserved.