SYNTHESIS OF 2,2-DIALKYL-1-AMINOCYCLOPROPANECARBOXYLIC ACIDS FROM ALPHA-CHLORO KETIMINES
SYNTHESIS OF 2,2-DIALKYL-1-AMINOCYCLOPROPANECARBOXYLIC ACIDS FROM ALPHA-CHLORO KETIMINES
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DOI：
10.1021/jo00309a023
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发表时间：
1990-10-26
影响因子：
3.6
通讯作者：
BRUNET, P
中科院分区：
文献类型：
--
作者：
DEKIMPE, N;SULMON, P;BRUNET, P
2，2-二烷基-1-氨基环丙烷羧酸（2，2-dialkyl-1-aminocyclopropanecarboxylic acid，简称2，2-dialkylAcc's）是一种很有潜力的植物生长调节剂。这些Acc类似物的合成方案需要新开发的区域特异性合成叔氯酮亚胺，用氰化物捕获短暂的Favorskii衍生的环丙叉基胺，和水解转化1-（N-叔丁基氨基）-2，2-二烷基环丙烷甲腈为标题化合物。
2, 2-Dialkyl-l-aminocyclopropanecarboxylic acids, abbreviated as 2, 2-dialkyl Acc’s, are potential plant growth regulators which were synthesized by ring closure of-chloro¡ mines. The synthetic scheme leading to these Acc analogues entails a newly developed regiospecific synthesis oftertiary-chloro ketimines, the trapping with cyanide of a transient Favorskii derived cyclopropylideneamine, and the hydrolytic conversion of 1-(N-tertbutylamino)-2, 2-dialkylcyclopropanecarbonitriles into the title compounds.