Preparation of gelatin/PVA nanofibers and their potential application in controlled release of drugs
Preparation of gelatin/PVA nanofibers and their potential application in controlled release of drugs
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DOI：
10.1016/j.carbpol.2007.01.008
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发表时间：
2007-06
影响因子：
11.2
通讯作者：
Dongzhi Yang;Yanning Li;J. Nie
中科院分区：
文献类型：
--
作者：
Dongzhi Yang;Yanning Li;J. Nie
采用静电纺丝法制备了明胶/聚乙烯醇（PVA）双组分纳米纤维，并研究了其对乌藨子酮（RK）的控制释放。随着PVA含量的增加，共混物的粒径增大，拉伸强度和断裂伸长率提高。药物在第一小时内观察到突释，并在两小时后达到平台。RK的释放速率可通过凝胶/聚乙烯醇的比例、RK的含量和戊二醛蒸汽交联时间来调节。
Gelatin/PVA bicomponent nanofibers were prepared via electrospinning, and its control release of Raspberry ketone(RK) was investigated. Significant diameter increase, tensile strength and elongation at break improvement were observed as the ratio of PVA increased. The burst release of drug was observed in the first hour, and reached a plateau after two hours. The RK release rate could be tailored by the GEL/PVA ratio, the content of loaded RK, and the crosslinking time of glutaraldehyde vapor.