Selection and fitness in bacteriocin-producing bacteria
Selection and fitness in bacteriocin-producing bacteria
复制标题
DOI：
10.1098/rspb.1997.0097
复制
发表时间：
1997-05-22
影响因子：
4.7
通讯作者：
Hastings, JW
中科院分区：
文献类型：
--
作者：
Dykes, GA;Hastings, JW
细菌素是由细菌产生的针对密切相关物种的蛋白质类抗竞争分子。许多理论模型已被用来解释实验数据，表明细菌素之间的高度多态性和频率依赖性的选择细菌素生产菌株。然而，这些实验数据中的大多数是从革兰氏阴性菌产生的细菌素的大肠杆菌素组的研究中获得的。从这些模型中得出的结论已被外推到其他细菌素和一般的化感化合物。最近对革兰氏阳性菌细菌素的实验研究表明，与产大肠杆菌素的菌株相比，这些菌株之间的多态性程度较低，选择的频率依赖性较低。在这里，我们根据理论模型和报告数据的假设和结论来研究这些矛盾。我们表明，健身成本（如相对最大增长率下降所示）与细菌素生产可能会在许多情况下比假设在本模型中低得多。与细菌素生产相关的较低的适应性成本充分解释了这里引用的革兰氏阳性菌的最新数据，并表明将现有模型外推到所有细菌素和其他化感化合物是不合适的。
Bacteriocins are proteinaceous anticompetitor molecules produced by bacteria against closely related species. A number of theoretical models have been used to explain experimental data that indicate high polymorphisms among bacteriocins and a frequency-dependent nature of selection for bacteriocin-producing strains. The majority of these experimental data were, however, obtained from investigations into the colicin group of bacteriocins produced by Gram-negative bacteria. The conclusions drawn from these models have been extrapolated to other bacteriocins and allelopathic compounds in general. Examination of more recent experimental investigations into the bacteriocins of Gram-positive bacteria indicate a lower degree of polymorphism and a less frequency-dependent mode of selection among these strains than among the colicin-producing strains. Here we examine these contradictions in the light of the assumptions and conclusions of the theoretical models and reported data. We show that fitness costs (as indicated by decreased relative maximum growth rate) associated with bacteriocin production may be much lower in many cases than is assumed in the present models. A lower fitness cost associated with bacteriocin production adequately explains the newer data from Gram-positive bacteria cited here, and indicates that extrapolation of existing models to all bacteriocins and other allelopathic compounds is not appropriate.