Mineralization of Basement Membrane Mediates Dentogingival Adhesion in Mammalian and Nonmammalian Vertebrates
Mineralization of Basement Membrane Mediates Dentogingival Adhesion in Mammalian and Nonmammalian Vertebrates
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基底膜矿化介导哺乳动物和非哺乳动物脊椎动物的牙龈粘附
DOI：
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发表时间：
2003
影响因子：
4.2
通讯作者：
S. Inoue
中科院分区：
文献类型：
--
作者：
T. Sawada;S. Inoue
为了阐明牙龈和牙齿之间的粘附机制，我们对猴和鲨鱼的牙龈缘进行了详细的超微结构比较研究。制备脱矿或不脱矿的组织用于超微结构观察。在边界，内部基底膜，这是牢固地结合到交界上皮通过半桥粒，是专门在这些物种不同。在猴子中，致密板在其釉质侧与具有致密板特征的附加层紧密相关，并被称为补充致密板。在鲨鱼，致密板表现出一种独特的，半桥粒相关的专业化的形式间歇性发生的凸起沿着其表面面向上皮。在nondemineralized组织的基底膜的一部分，即，补充层致密（猴）和主要层致密，但不是隆起（鲨鱼），优先矿化。矿物存款是连续的，在釉质和釉质/牙本质，从而构成了一个先进的边缘矿化。猴基底膜中矿物晶体的网络排列类似于基底膜的索状网络的图案，表明存在微妙的相互基底膜-矿物相互作用。因此，允许有机相和矿物相在基膜的该矿化区域处接触并彼此牢固地结合。因此，强大的牙龈-牙齿粘附是通过内部基底膜的部分矿化建立的，其方式类似于先前报道的成熟阶段成釉细胞与釉质的相关性。
In order to elucidate the mechanism of adhesion between the gingiva and the tooth, detailed comparative ultrastructural studies of the dentogingival border were done in the monkey and shark. The tissues were prepared with or without demineralization for the ultrastructural observations. At the border, the internal basement membrane, which is firmly bound to the junctional epithelium through hemidesmosomes, was specialized differently in these species. In the monkey, the lamina densa was closely associated at its enamel side with an additional layer which had characteristics of the lamina densa and was referred to as the supplementary lamina densa. In the shark, the lamina densa showed a unique, hemidesmosome-related specialization in the form of the intermittent occurrence of bulges along its surface facing the epithelium. In nondemineralized tissues a part of the basement membrane, that is, the supplementary lamina densa (monkey) and the main lamina densa but not bulges (shark), was preferentially mineralized. The mineral deposit was continuous with that in the enamel and enameloid/dentine, thus constituting an advancing edge of mineralization. The network arrangement of the mineral crystals in the monkey basement membrane resembled the pattern of the cord network of the basement membrane, suggesting the presence of a delicate mutual basement membrane–mineral interaction. Thus, the organic phase and the mineral phase are allowed to make contact at this mineralized area of the basement membrane and firmly bind to one another. Therefore, strong gingiva–tooth adhesion is established by partial mineralization of the internal basement membrane, in a way similar to that found in the previously reported association of maturation stage ameloblasts with the enamel.
DOI：
10.1002/aja.1001810403
发表时间：
1988
期刊：
The American journal of anatomy
影响因子：
--
作者：
Inoue,S;Leblond,CP
通讯作者：
Leblond,CP