External validation of the SOX-PTS score in a prospective multicenter trial of patients with proximal deep vein thrombosis.
External validation of the SOX-PTS score in a prospective multicenter trial of patients with proximal deep vein thrombosis.
复制标题
DOI：
10.1111/jth.14791
复制
发表时间：
2020-06
期刊：
影响因子：
--
通讯作者：
ATTRACT Trial Investigators
中科院分区：
文献类型：
--
作者：
Rabinovich A;Gu CS;Vedantham S;Kearon C;Goldhaber SZ;Gornik HL;Kahn SR;ATTRACT Trial Investigators
利用SOX试验的数据，我们最近开发了一种近端深静脉血栓形成（DVT）后血栓后综合征（PTS）发生的临床预测模型，称为SOX-PTS评分。评分包括DVT的解剖学范围;体重指数;和基线Villalta评分。外部确认SOX-PTS评分。ATTRACT试验数据的Logistic回归分析，该试验评价了近端DVT患者的药物机械导管定向溶栓。主要结局是DVT后6 - 24个月PTS（定义为Villalta评分≥ 5）的发生率。次要结局包括中重度PTS（Villalta量表≥ 10）和重度PTS（Villalta量表≥ 14）。预测性能进行了评估的歧视和校准。在探索性分析中评估了更新后的评分。纳入了691例ATTRACT患者，其中328例（47%）发生了PTS。PTS的c-统计量为0.63; 95%置信区间（CI）为0.59-0.67。对于中重度PTS和重度PTS的结局，该模型的性能似乎更好（中重度PTS的c-统计量为0.67; 95% CI为0.62 - 0.72，重度PTS为0.70; 0.64 - 0.77）。将年龄作为额外变量的更新模型与原始模型相似。我们外部验证了SOX-PTS评分用于估计近端DVT患者发生PTS、中度至重度PTS和重度PTS的风险。该评分可能有助于预测DVT诊断时的PTS。需要在不同的患者队列中进行进一步的外部验证。
Using data from the SOX Trial, we recently developed a clinical prediction model for occurrence of the post-thrombotic syndrome (PTS) after proximal deep vein thrombosis (DVT), termed the SOX-PTS score. The score includes anatomical extent of DVT; body mass index; and baseline Villalta score. To externally validate the SOX-PTS score. Logistic regression analysis of data from the ATTRACT Trial which evaluated pharmacomechanical catheter directed thrombolysis in patients with proximal DVT. The primary outcome was the occurrence of PTS (defined as Villalta score ≥ 5) from 6 to 24 months after DVT. Secondary outcomes included moderate-severe PTS (Villalta scale ≥ 10) and severe PTS (Villalta scale ≥ 14). Predictive performance was assessed by discrimination and calibration. An updated score was evaluated in an exploratory analysis. 691 ATTRACT patients were included, of whom 328 (47%) developed PTS. The c-statistic was 0.63; 95% confidence interval (CI) 0.59-0.67 for PTS. The model's performance appeared to be better for the outcomes moderate to severe PTS and severe PTS (c-statistic 0.67; 95% CI 0.62 to 0.72 for moderate-severe PTS and 0.70; 0.64 to 0.77 for severe PTS). An updated model with age as an additional variable performed similarly to the original model. We externally validated the SOX-PTS score for estimating the risk of developing PTS, moderate to severe PTS, and severe PTS, in patients with proximal DVT. The score may be useful to predict PTS at the time of DVT diagnosis. Further external validation in different patient cohorts is required.
登录
查看更多内容
DOI：
10.1056/nejmoa1615066
发表时间：
2017-12-07
期刊：
The New England journal of medicine
影响因子：
--
作者：
Vedantham S;Goldhaber SZ;Julian JA;Kahn SR;Jaff MR;Cohen DJ;Magnuson E;Razavi MK;Comerota AJ;Gornik HL;Murphy TP;Lewis L;Duncan JR;Nieters P;Derfler MC;Filion M;Gu CS;Kee S;Schneider J;Saad N;Blinder M;Moll S;Sacks D;Lin J;Rundback J;Garcia M;Razdan R;VanderWoude E;Marques V;Kearon C;ATTRACT Trial Investigators
通讯作者：
ATTRACT Trial Investigators
影响因子：
9.6
作者：
Kearon, Clive;Akl, Elie A.;Moores, Lisa
通讯作者：
Moores, Lisa
DOI：
10.1016/j.jvir.2014.04.019
发表时间：
2014-09-01
影响因子：
2.9
作者：
Vedantham, Suresh;Sista, Akhilesh K.;Nikolic, Boris
通讯作者：
Nikolic, Boris
影响因子：
6.7
作者：
Amin, Elham E.;van Kuijk, Sander M. J.;ten Cate-Hoek, Arina J.
通讯作者：
ten Cate-Hoek, Arina J.
DOI：
10.1111/j.2517-6161.1977.tb01600.x
发表时间：
1977-01-01
期刊：
JOURNAL OF THE ROYAL STATISTICAL SOCIETY SERIES B-METHODOLOGICAL
影响因子：
--
作者：
DEMPSTER, AP;LAIRD, NM;RUBIN, DB
通讯作者：
RUBIN, DB