Reshaping neuron-glial communication at hippocampal synapses
Reshaping neuron-glial communication at hippocampal synapses
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DOI：
10.1017/s1740925x06000032
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发表时间：
2006-01-01
影响因子：
--
通讯作者：
Murai, Keith K.
中科院分区：
文献类型：
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作者：
Haber, Michael;Murai, Keith K.
神经系统中神经元与神经胶质的相互作用对神经迁移、轴突引导、髓鞘形成和突触传递等过程具有重要意义。在中枢神经系统的突触中，神经元和星形胶质细胞之间的生理和结构关系尤为复杂。星形细胞膜与突触前和突触后元件的并置对调节突触传递和可塑性具有重要意义。最近的研究表明，海马神经元和胶质成分的形态表现出快速、持续的结构重塑。这些物理改变可能对神经传递有重要的功能影响，并表明星形细胞形态的重塑可能对突触及其微环境的动态调节至关重要。在这篇综述中，我们关注海马星形胶质细胞-突触相互作用的结构复杂性及其对理解突触生理、行为和疾病的意义。
Neuron-glial interactions in the nervous system are of fundamental importance to many processes including neural migration, axon guidance, myelination and synaptic transmission. At synapses in the CNS, the physiological and structural relationship between neurons and astrocytes is particularly complex. The juxtaposition of astrocytic membranes with presynaptic and postsynaptic elements is important for regulating synaptic transmission and plasticity. Recent investigations demonstrate that the morphology of both neuronal and glial components show rapid, continuous structural remodeling in the hippocampus. These physical modifications are likely to have a significant functional impact upon neurotransmission and indicate that the remodeling of astrocytic morphology might be crucial for the dynamic regulation of the synapse and its microenvironment. In this review, we focus on the structural complexities of astrocyte-synapse interactions in the hippocampus and their implications for understanding synaptic physiology, behavior and disease.