Evidence of a substantial genetic basis for risk of adult periodontitis
Evidence of a substantial genetic basis for risk of adult periodontitis
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DOI：
10.1902/jop.2000.71.11.1699
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发表时间：
2000-11-01
影响因子：
4.3
通讯作者：
Schenkein, HA
中科院分区：
文献类型：
--
作者：
Michalowicz, BS;Diehl, SR;Schenkein, HA
背景：一些先前的研究表明成人牙周炎（AP）的风险有遗传（遗传）成分。我们估计牙龈炎和成人牙周炎的遗传和环境的方差和遗传力使用的数据从双胞胎raised together.Methods：一百一十七（117）对成年双胞胎（64单卵[MZ]和53双卵[DZ]对）被招募。由两名检查员对所有牙齿的探测深度（PD）、附着丧失（AL）、菌斑和牙龈炎（GI）进行评估。所有部位、牙齿和检查者的测量值取平均值。受试者的疾病程度定义在四个阈值：AL大于或等于2，AL大于或等于3，PD大于或等于4，或PD大于或等于5 mm的牙齿的百分比。遗传和环境的方差和遗传力估计使用路径模型与最大似然estimation techniques.Results：MZ双胞胎比DZ双胞胎更相似的所有临床措施。统计学上显着的遗传变异被发现的严重程度和疾病的范围。据估计，AP具有约50%的遗传性，在对包括吸烟在内的行为变量进行调整后，遗传性没有改变。相比之下，虽然MZ双胞胎也比DZ双胞胎的牙龈炎评分相似，有没有证据表明牙龈炎的遗传性后，行为协变量，如利用牙齿护理和吸烟被纳入到analysis.Conclusions：这些结果证实了以前的研究，并表明，大约一半的人口中的疾病的方差是由于遗传方差。牙周炎的遗传基础似乎是生物学的，而不是行为学的。
Background: A few previous studies have suggested that risk for adult periodontitis (AP) has a genetic (heritable) component. We estimated genetic and environmental variances and heritability for gingivitis and adult periodontitis using data from twins reared together.Methods: One hundred seventeen (117) pairs of adult twins (64 monozygotic [MZ] and 53 dizygotic [DZ] pairs) were recruited. Probing depth (PD), attachment loss (AL), plaque, and gingivitis (GI) were assessed on all teeth by two examiners. Measurements were averaged over all sites, teeth, and examiners. Extent of disease in subjects was defined at four thresholds: the percentage of teeth with AL greater than or equal to2, AL greater than or equal to3, PD greater than or equal to4, or PD greater than or equal to5 mm. Genetic and environmental variances and heritability were estimated using path models with maximum likelihood estimation techniques.Results: MZ twins were more similar than DZ twins for all clinical measures. Statistically significant genetic variance was found for both the severity and extent of disease. AP was estimated to have approximately 50% heritability, which was unaltered following adjustments for behavioral variables including smoking. In contrast, while MZ twins were also more similar than DZ twins for gingivitis scores, there was no evidence of heritability for gingivitis after behavioral covariates such as utilization of dental care and smoking were incorporated into the analyses.Conclusions: These results confirm previous studies and indicate that approximately half of the variance in disease in the population is attributed to genetic variance. The basis for the heritability of periodontitis appears to be biological and not behavioral in nature.