Effects of Maternal Abdominal Surgery on Fetal Brain Development in the Rabbit Model.
Effects of Maternal Abdominal Surgery on Fetal Brain Development in the Rabbit Model.
复制标题
DOI：
10.1159/000512489
复制
发表时间：
2021
影响因子：
2.2
通讯作者：
Rex S
中科院分区：
文献类型：
--
作者：
Bleeser T;Van Der Veeken L;Devroe S;Vergote S;Emam D;van der Merwe J;Ghijsens E;Joyeux L;Basurto D;Van de Velde M;Deprest J;Rex S
Anesthesia during pregnancy can impair fetal neurodevelopment, but effects of surgery remain unknown. The aim is to investigate effects of abdominal surgery on fetal brain development. Hypothesis is that surgery impairs outcome. Pregnant rabbits were randomized at 28 days of gestation to 2 h of general anesthesia (sevoflurane group, n = 6) or to anesthesia plus laparoscopic appendectomy (surgery group, n = 13). On postnatal day 1, neurobehavior of pups was assessed and brains harvested. Primary outcome was neuron density in the frontal cortex, and secondary outcomes included neurobehavioral assessment and other histological parameters. Fetal survival was lower in the surgery group: 54 versus 100% litters alive at birth (p = 0.0442). In alive litters, pup survival until harvesting was 50 versus 69% (p = 0.0352). No differences were observed for primary outcome (p = 0.5114) for surviving pups. Neuron densities were significantly lower in the surgery group in the caudate nucleus (p = 0.0180), but not different in other regions. No differences were observed for secondary outcomes. Conclusions did not change after adjustment for mortality. Abdominal surgery in pregnant rabbits at a gestational age corresponding to the end of human second trimester results in limited neurohistological changes but not in neurobehavioral impairments. High intrauterine mortality limits translation to clinical scenario, where fetal mortality is close to zero.
登录
查看更多内容
影响因子：
5.7
作者：
DiMaggio C;Sun LS;Li G
通讯作者：
Li G
影响因子：
2.5
作者：
DOBBING, J;SANDS, J
通讯作者：
SANDS, J
影响因子：
9
作者：
Balinskaite, Violeta;Bottle, Alex;Aylin, Paul
通讯作者：
Aylin, Paul
影响因子：
8.8
作者：
Brambrink AM;Evers AS;Avidan MS;Farber NB;Smith DJ;Martin LD;Dissen GA;Creeley CE;Olney JW
通讯作者：
Olney JW
影响因子：
25
作者：
Aarts, Emmeke;Verhage, Matthijs;van der Sluis, Sophie
通讯作者：
van der Sluis, Sophie