Heritability of blood pressure responses to dietary sodium and potassium intake in a Chinese population
Heritability of blood pressure responses to dietary sodium and potassium intake in a Chinese population
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DOI：
10.1161/hypertensionaha.107.088310
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发表时间：
2007-07-01
期刊：
影响因子：
8.3
通讯作者：
He, Jiang
中科院分区：
文献类型：
--
作者：
Gu, Dongfeng;Rice, Treva;He, Jiang
血压对饮食干预反应的遗传性尚未得到很好的研究。我们对1906名居住在中国北方农村的家庭喂养研究参与者进行了血压对膳食钠和钾摄入量反应的遗传性研究。饮食干预包括7 d低钠喂养（51.3 mmol / d）、7 d高钠喂养（307.8 mmol / d）和7 d高钠加钾补充（60 mmol / d）。在干预前的3天基线期间和每个干预阶段的最后3天，使用随机零血压计测量血压9次。遗传力是在计算机程序SOLAR中实现的方差成分模型下使用最大似然法计算的。基线血压的遗传率收缩压为0.31，舒张压为0.32，平均动脉压为0.34。饮食干预组遗传力显著增加，低钠组遗传力分别为0.49、0.49和0.51；高钠时分别为0.47、0.49和0.51；补充钾的收缩压、舒张压和平均动脉压分别为0.51、0.52和0.53。低钠血压反应百分比的遗传率分别为0.20、0.21和0.23；高钠的分别为0.22、0.33和0.33；而补充钾对收缩压、舒张压和平均动脉压的影响分别为0.24、0.21和0.25。我们的研究表明，控制饮食钠和钾摄入量的血压遗传率明显高于正常饮食的血压遗传率。此外，在本研究人群中，饮食钠和钾摄入量对血压反应的遗传力是中等的。
The heritability of blood pressure responses to dietary intervention has not been well studied. We examined the heritability of blood pressure responses to dietary sodium and potassium intake in a family feeding study among 1906 study participants living in rural North China. The dietary intervention included a 7-day low-sodium feeding (51.3 mmol per day), a 7-day high-sodium feeding (307.8 mmol per day), and a 7-day high-sodium plus potassium supplementation (60 mmol per day). Blood pressure was measured 9 times during the 3-day baseline period preceding the intervention and also during the last 3 days of each intervention phase using a random-zero sphygmomanometer. Heritability was computed using maximum likelihood methods under a variance components model as implemented in the computer program SOLAR. The heritabilities of baseline blood pressure were 0.31 for systolic, 0.32 for diastolic, and 0.34 for mean arterial pressure. The heritabilities increased significantly under dietary intervention and were 0.49, 0.49, and 0.51 during low sodium; 0.47, 0.49, and 0.51 during high sodium; and 0.51, 0.52, and 0.53 during potassium supplementation for systolic, diastolic, and mean arterial pressure, respectively. The heritabilities for percentage of blood pressure responses to low sodium were 0.20, 0.21, and 0.23; to high-sodium were 0.22, 0.33, and 0.33; and to potassium supplementation were 0.24, 0.21, and 0.25 for systolic, diastolic, and mean arterial pressure, respectively. Our study indicated that the heritabilities of blood pressure under controlled dietary sodium and potassium intake were significantly higher than those under a usual diet. In addition, the heritabilities of blood pressure responses to dietary sodium and potassium intake were moderate in this study population.