Exploring the early origins of the synapse by comparative genomics
Exploring the early origins of the synapse by comparative genomics
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DOI：
10.1098/rsbl.2008.0594
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发表时间：
2009-02-23
期刊：
影响因子：
3.3
通讯作者：
Kosik, Kenneth S.
中科院分区：
文献类型：
--
作者：
Kosik, Kenneth S.
细胞机器的进化是一组进化特征，与基因或物种的进化相比，它受到的关注较少。细胞机器是细胞中具有专门功能的独立结构。在这里，我认为通过改组，复制和蛋白质表达水平的变化域扩展是细胞机器进化的关键驱动力。一旦建立，这些细胞机器的进化变化往往会通过旁系关系或现有核心基因的扩展和修改而发生。一个比较基因组学方法的一个细胞机器-突触后复合体-提供了初步验证这些观点。对整个细胞组的比较基因组学方法可以揭示细胞机器的多样性及其相互关系。
One set of evolutionary features that has received less attention than the evolution of genes or species is the evolution of cellular machines, the self-contained structures in cells with dedicated functions. Here I suggest that domain expansion through shuffling, duplication, and changes in protein expression level are critical drivers in the evolution of cellular machines. Once established, evolutionary change in these cellular machines tends to occur by paralogy or expansion and modification of the existing core genes. A comparative genomics approach to one cellular machine-the postsynaptic complex-provided preliminary validation of these views. A comparative genomics approach to the entire cellulome may reveal the diversity of cellular machines and their inter-relationships.