ULTRASTRUCTURAL-STUDY OF NORMAL MUCOSA-ADENOMA-CANCER SEQUENCE IN DEVELOPMENT OF FAMILIAL POLYPOSIS COLI
ULTRASTRUCTURAL-STUDY OF NORMAL MUCOSA-ADENOMA-CANCER SEQUENCE IN DEVELOPMENT OF FAMILIAL POLYPOSIS COLI
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DOI：
10.1093/jnci/60.4.753
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发表时间：
1978-01-01
影响因子：
10.3
通讯作者：
FILIPE, MI
中科院分区：
文献类型：
--
作者：
MUGHAL, S;FILIPE, MI
研究了家族性大肠息肉病患者结肠上皮的超微结构变化。建立了从对照组的正常粘膜，通过息肉和腺瘤之间的正常粘膜，到浸润性癌的渐强变化的分级标准。标准是基于成熟和未成熟吸收细胞中的小电子致密体（分泌颗粒）和溶酶体的囊泡和数量增加，未成熟和未分化细胞的存在，杯状细胞的变化以及非典型分泌细胞的外观和核改变。结果说明了腺瘤-癌的序列，并增加了支持其发生的有力证据。超微结构研究揭示了腺瘤生长之前的细胞变化，可能作为早期癌症的标志物。本研究还揭示了粘膜上皮的功能与形态之间的密切联系。
Ultrastructural changes that occurred in the colon epithelia of patients with familial polyposis coli were investigated. Criteria of gradation of the crescendo changes from the normal mucosa in the controls, through the normal mucosa between polyps and adenomas in various stages of dedifferentiation, to invasive carcinoma were established. The criteria were based on vesiculation and increasing numbers of small electron-dense bodies (secretory granules) and lysosomes in the mature and immature absorptive cells, presence of immature and undifferentiated cells, variation in the goblet cells and appearance of atypical secretory cells and nuclear changes. The results illustrated the adenoma-carcinoma sequence and added strong evidence to support its occurrence. This ultrastructural study revealed cellular changes that preceded adenomatous growth and may be of value as markers of early stages of cancer. This study also revealed a close link between function and morphology of the mucosal epithelium.