Effects of Levetiracetam Compared to Valproate on Cognitive Functions of Patients with Epilepsy
Effects of Levetiracetam Compared to Valproate on Cognitive Functions of Patients with Epilepsy
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DOI：
10.2147/ndt.s256117
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发表时间：
2020-01-01
影响因子：
3.2
通讯作者：
Sarhan, Hatem A.
中科院分区：
文献类型：
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作者：
El Sabaa, Ramy M.;Hamdi, Emad;Sarhan, Hatem A.
目的：本研究比较了左乙拉西坦（LEV）作为单药治疗丙戊酸钠（VPA）作为单药治疗对癫痫患者认知功能的影响。患者选自Minia University Hospital（Minia，Egypt）的神经科门诊。分为LEV治疗组和VPA治疗组。治疗前及治疗后3个月分别采用反应时测验、连线测验、威斯康星州卡片分类测验对所有患者进行认知功能评估。然而，LEV患者在开始治疗3个月后测得的认知功能显着改善，而VPA组患者在开始治疗3个月后测得的认知功能显着受损。结论：两组患者均显示癫痫发作频率降低。然而，LEV组患者在开始治疗3个月后测得的认知功能显示出显著改善，而VPA组患者在开始治疗3个月后测得的认知功能显示出显著损害。
Objective: This study compared the effect of levetiracetam (LEV) as monotherapy to sodium valproate (VPA) as monotherapy on cognitive functions in patients with epilepsy.Methods: This was a comparative prospective study on 50 patients with newly diagnosed epilepsy started on antiseizure medications. Patients were selected from the neurology-outpatient clinics at Minia University Hospital, Minia, Egypt. They were divided into two groups: group treated with LEV and group treated with VPA. All patients were subjected to cognitive function assessment using reaction-time tests, trail-making tests, and Wisconsin card-sorting test before treatment and 3 months after treatment.Results: Both groups of patients showed reduction in seizure frequency. However, patients on LEV showed significant improvement in measured cognitive functions 3 months after starting treatment, while patients in the VPA group showed significant impairment in measured cognitive functions 3 months after starting treatment.Conclusion: Both groups of patients showed reduction in seizure frequency. However, patients on LEV showed significant improvement in measured cognitive functions 3 months after starting treatment, while patients in the VPA group showed significant impairment in measured cognitive functions 3 months after starting treatment.