BENEFICIAL EFFECT OF ANISODAMINE IN HEMORRHAGIC-SHOCK
BENEFICIAL EFFECT OF ANISODAMINE IN HEMORRHAGIC-SHOCK
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DOI：
10.1007/bf00504382
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发表时间：
1984-01-01
影响因子：
3.6
通讯作者：
LEFER, AM
中科院分区：
文献类型：
--
作者：
SU, JY;HOCK, CE;LEFER, AM
山莨菪碱是从唐古特山莨菪碱中提取的生物碱，在我国被广泛用于治疗感染性休克，但其作用机制尚不清楚。在控制良好的失血性休克猫中研究了其抗休克作用。在MABP [平均动脉血压]稳定在40-45 min Hg后20 min，静脉推注1 mg/kg剂量，然后在低血期静脉输注2 mg/kg/h。再输注后2小时，MABP显著升高（106 ± 0.01）。10 mm Hg），而在仅接受载体的休克猫中（53 . ±. 6 mm Hg，P < 0.001）。山莨菪碱治疗组的组织蛋白酶D活性和氨基氮含量均显著低于对照组（P < 0.001）。在未处理的休克猫中，血浆心肌细胞因子（TNF）活性显著增加（61 ± 0.01）。6 U/ml），但山莨菪碱（32 . ±. 5U/ml，P < 0.01）。山莨菪碱不能增加失血性休克模型的上级肠系膜动脉血流量（SMAF），因为两个休克组之间的SMAF没有显著差异。山莨菪碱的有益作用可能不是由于内脏血管的血管舒张。体外分析表明，该药物在猫胰腺匀浆中具有直接的抗蛋白水解作用。这可能部分解释了其作用机制，这似乎是复杂的。
Ansiodamine, an alkaloid extracted from Anisodus tanguticus, is widely used in China in the treatment of septic shock, but its mechanism of action is unknown. Its antishock action in cats was studied in a well controlled and hemorrhagic shock. A bolus dose of 1 mg/kg was given i.v. 20 min after MABP [mean arterial blood pressure] was stabilized at 40-45 min Hg, followed by i.v. infusion of 2 mg/kg per h during the oligemic period. Two hours post-reinfusion, MABP was significantly higher (106 .+-. 10 mm Hg) in the drug-treated group than in shock cats receiving only vehicle (53 .+-. 6 mm Hg, P < 0.001). Anisodamine treated shock cats exhibited significantly lower cathepsin D activity (P < 0.02) and amino-nitrogen concentration (P < 0.001) than untreated shock animals. Plasma myocardial depressant factor (MDF) activity was significantly increased in the untreated shock cats (61 .+-. 6 U/ml), but the plasma accumulation of MDF was significantly blunted by anisodamine (32 .+-. 5 U/ml, P < 0.01). Anisodamine did not increase superior mesenteric artery flow (SMAF) in this model of hemorrhagic shock as there was no significant difference in SMAF between the 2 shocked groups. The beneficial effect of anisodamine probably is not due to vasodilation of the splanchnic vasculature. In vitro analysis indicates that the drug has a direct anti-proteolytic action in cat pancreatic homogenates. This may partly explain the mechanism of its action, which appears to be complex.