Association of asthma and smoking with lung function impairment in adolescence and early adulthood: the Isle of Wight Birth Cohort Study
Association of asthma and smoking with lung function impairment in adolescence and early adulthood: the Isle of Wight Birth Cohort Study
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DOI：
10.1183/13993003.00477-2019
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发表时间：
2020-03-01
影响因子：
24.3
通讯作者：
Roberts, Graham
中科院分区：
文献类型：
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作者：
Arshad, S. Hasan;Hodgekiss, Claire;Roberts, Graham
我们调查了从儿童期到成年早期哮喘和吸烟与肺功能和气道可逆性的关系。对怀特岛出生队列 (n=1456) 在出生时以及 1、2、4、10、18 和 26 岁时进行了评估。哮喘被定义为医生诊断加上当前喘息和/或治疗。在 10 岁（n=981）、18 岁（n=839）和 26 岁（n=547）时进行肺活量测定。根据哮喘和 26 岁时的吸烟状况，将个体细分为不吸烟但患有哮喘、不吸烟但患有哮喘、吸烟但不患有哮喘和吸烟者患有哮喘。使用纵向模型检查他们 10 至 26 岁时的肺功能轨迹。 与 10 岁和 18 岁时无哮喘的非吸烟者相比，患有哮喘的非吸烟者 1 秒用力呼气量 (FEV1)、FEF25-75%（用力肺活量 (FVC) 25-75% 时的用力呼气流量）和 FEV1/FVC 比值较小，使用支气管扩张剂后差异减小（使用支气管扩张剂前 FEV1，26 岁时为 3.75 L 与 4.02 L，p
We investigated associations of asthma and smoking with lung function and airway reversibility from childhood to early adulthood.The population-based Isle of Wight Birth Cohort (n=1456) was assessed at birth, and at 1, 2, 4, 10, 18 and 26 years. Asthma was defined as physician diagnosis plus current wheeze and/or treatment. Spirometry was conducted at 10 (n=981), 18 (n=839) and 26 years (n=547). Individuals were subdivided into nonsmokers without asthma, nonsmokers with asthma, smokers without asthma and smokers with asthma, based on asthma and smoking status at 26 years. Their lung function trajectories from 10 to 26 years were examined using longitudinal models.Nonsmokers with asthma had smaller forced expiratory volume in 1 s (FEV1), FEF25-75% (forced expiratory flow at 25-75% of forced vital capacity (FVC)) and FEV1/FVC ratio compared to nonsmokers without asthma at age 10 and 18 years, with differences reduced after bronchodilator (pre-bronchodilator FEV1 at 26 years 3.75 L versus 4.02 L, p