IN-VIVO MYOCARDIAL KINETICS OF AIR-FILLED ALBUMIN MICROBUBBLES DURING MYOCARDIAL CONTRAST ECHOCARDIOGRAPHY - COMPARISON WITH RADIOLABELED RED-BLOOD-CELLS
IN-VIVO MYOCARDIAL KINETICS OF AIR-FILLED ALBUMIN MICROBUBBLES DURING MYOCARDIAL CONTRAST ECHOCARDIOGRAPHY - COMPARISON WITH RADIOLABELED RED-BLOOD-CELLS
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DOI：
10.1161/01.res.74.6.1157
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发表时间：
1994-06-01
影响因子：
20.1
通讯作者：
KAUL, S
中科院分区：
文献类型：
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作者：
JAYAWEERA, AR;EDWARDS, N;KAUL, S
心肌造影超声心动图（MCE）是一种通过在冠状动脉内注入空气微泡来评估心肌灌注的新技术。由于这些微泡的平均直径为4.3+/-0.3 μ m，并且血管内结构与红细胞相似，我们假设超声心动图记录的平均心肌转运率可以提供体内跳动心脏区域心肌血流量的估计。据此，将12只开胸麻醉犬（I组）的左冠状动脉前降支（LAD）血流调整为4 ~ 6流（共60流），并在每个阶段随机向LAD注入微泡和放射性标记红细胞。通过将微型CsI2探针放置在心脏前表面上产生的时间-活动图拟合伽马变量函数来测量心肌红细胞平均转运率，通过对注射微泡期间获得的MCE图像进行离线分析得出的时间-强度图来测量心肌微泡平均转运率。血流（用体外电磁血流探头测量）与平均心肌红细胞转运率之间存在极好的相关性(y=2.83x10(-3)x+0.01, r= 0.96， SEE=0.02， P
Myocardial contrast echocardiography (MCE) is a new technique for assessing myocardial perfusion that uses intracoronary injections of microbubbles of air. Because these microbubbles have a mean diameter of 4.3+/-0.3 mu m and an intravascular theology similar to that of red blood cells (RBCs), we hypothesized that their mean myocardial transit rates recorded on echocardiography would provide an estimation of regional myocardial blood flow in the in vivo beating heart. Accordingly, blood flow to the left anterior descending coronary artery (LAD) of 12 open-chest anesthetized dogs (group I) was adjusted to 4 to 6 flows (total of 60 flows), and microbubbles and radiolabeled RBCs were injected into the LAD in a random order at each stage. The mean myocardial RBC transit rates were measured by fitting a gamma-variate function to time-activity plots generated by placing a miniature CsI2 probe over the anterior surface of the heart, and the mean myocardial microbubble transit rates were measured from time-intensity plots derived from off-line analysis of MCE images obtained during the injection of microbubbles. An excellent correlation was noted between flow (measured with an extracorporeal electromagnetic flow probe) and mean myocardial RBC transit rate (y=2.83x10(-3)x+0.01, r=.96, SEE=0.02, P