Reactive gliosis and the multicellular response to CNS damage and disease.
Reactive gliosis and the multicellular response to CNS damage and disease.
复制标题
DOI：
10.1016/j.neuron.2013.12.034
复制
发表时间：
2014-01-22
期刊：
影响因子：
16.2
通讯作者：
Sofroniew MV
中科院分区：
文献类型：
--
作者：
Burda JE;Sofroniew MV
中枢神经系统（CNS）容易受到不同病因的异质性损伤，引起多方面的反应。急性和局灶性损伤触发组织置换的伤口修复。弥漫性和慢性疾病引起逐渐升级的组织变化。对CNS损伤的反应涉及许多谱系和功能的细胞之间的复杂相互作用，包括CNS内在神经细胞、CNS内在非神经细胞和从循环进入的CNS外在细胞。随着对理解和改善CNS疾病的推动加速，各种非神经元细胞类型对急性损伤后结果或慢性疾病进展的贡献越来越受到关注。在某些情况下，可以获得相当多的信息，在其他情况下，相对较少，如本文所研究和审查的那样。
The central nervous system (CNS) is prone to heterogeneous insults of diverse etiologies that elicit multifaceted responses. Acute and focal injuries trigger wound repair with tissue replacement. Diffuse and chronic diseases provoke gradually escalating tissue changes. The responses to CNS insults involve complex interactions among cells of numerous lineages and functions, including CNS intrinsic neural cells, CNS intrinsic non-neural cells, and CNS extrinsic cells that enter from the circulation. The contributions of diverse non-neuronal cell types to outcome after acute injury, or to the progression of chronic disease, are of increasing interest as the push towards understanding and ameliorating CNS afflictions accelerates. In some cases considerable information is available, in others, comparatively little, as examined and reviewed here.
登录
查看更多内容
影响因子：
15.3
作者：
Brambilla, R;Bracchi-Ricard, V;Hu, WH;Frydel, B;Bramwell, A;Karmally, S;Green, EJ;Bethea, JR
通讯作者：
Bethea, JR
影响因子：
6.2
作者：
Burda, Joshua E.;Radulovic, Maja;Yoon, Hyesook;Scarisbrick, Isobel A.
通讯作者：
Scarisbrick, Isobel A.
DOI：
10.1073/pnas.0808698106
发表时间：
2009-02-10
影响因子：
11.1
作者：
Argaw, Azeb Tadesse;Gurfein, Blake T.;John, Gareth R.
通讯作者：
John, Gareth R.
影响因子：
8.3
作者：
Bliss, Tonya;Guzman, Raphael;Steinberg, Gary K.
通讯作者：
Steinberg, Gary K.
影响因子：
11.2
作者：
Arumugam, Thiruma V.;Phillips, Terry M.;Cheng, Aiwu;Morrell, Christopher H.;Mattson, Mark P.;Wan, Ruiqian
通讯作者：
Wan, Ruiqian