Clinical significance of pleural effusion mesothelin in malignant pleural mesothelioma
Clinical significance of pleural effusion mesothelin in malignant pleural mesothelioma
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DOI：
10.1515/cclm.2011.242
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发表时间：
2011-10-01
影响因子：
6.8
通讯作者：
Nakano, Takashi
中科院分区：
文献类型：
--
作者：
Yamada, Shusai;Tabata, Chiharu;Nakano, Takashi
背景：恶性胸膜间皮瘤（MPM）是一种与石棉接触有关的侵袭性恶性肿瘤。MPM对常规化疗和放疗的反应有限，因此早期诊断MPM非常重要。本研究调查了MPM患者的胸腔积液间皮素水平，并将其与非恶性胸膜炎或肺癌伴恶性胸腔积液的人群进行了比较。对45例MPM患者和53例非MPM患者的胸腔积液进行了间皮素浓度测定（24名非恶性胸腔积液患者和29名肺癌患者涉及恶性胸腔积液）。该研究表明，MPM患者的胸腔积液间皮素水平显著高于非恶性胸膜炎或肺癌患者（涉及恶性胸腔积液）。胸腔积液间皮素水平低于和高于假设的截止值10 nM的组之间的总生存率的差异是显着的：数据表明，胸腔积液间皮素浓度可能是有用的，作为辅助诊断MPM。
Background: Malignant pleural mesothelioma (MPM) is an aggressive malignant tumor of mesothelial origin associated with asbestos exposure. MPM has a limited response to conventional chemotherapy and radiotherapy, so early diagnosis of MPM is very important. This study investigated the pleural effusion mesothelin levels in patients with MPM and compared them to those of a population with a non-malignant pleuritis or lung cancer involving malignant pleural effusion.Methods: The pleural effusion mesothelin concentrations were measured in 45 MPM patients and 53 non-MPM individuals (24 individuals with non-malignant pleural effusions and 29 individuals with lung cancer involving malignant pleural effusion).Results: This study demonstrated that patients with MPM had significantly higher pleural effusion mesothelin levels than a population with non-malignant pleuritis or lung cancer involving malignant pleural effusion. The difference in overall survival between the groups with pleural effusion mesothelin levels lower and higher than the assumed cut-off of 10 nM was significant.Conclusions: The data suggest that the pleural effusion mesothelin concentration could be useful as an aid for the diagnosis of MPM.