Risk factors for erosive and non-erosive gastroesophageal reflux disease and Barrett's esophagus in Nothern Sardinia
Risk factors for erosive and non-erosive gastroesophageal reflux disease and Barrett's esophagus in Nothern Sardinia
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DOI：
10.1080/00365521.2016.1200137
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发表时间：
2016-01-01
影响因子：
1.9
通讯作者：
Graham, David Yates
中科院分区：
文献类型：
--
作者：
Dore, Maria Pina;Pes, Giovanni Mario;Graham, David Yates
目的：胃食管反流病（GERD）和食管腺癌的发病率逐年上升。我们研究了传统的危险因素和幽门螺杆菌感染的关系，糜烂性和非糜烂性GERD和Barrett's esophageal.Materials和方法：这是一项回顾性研究消化不良患者进行上消化道内镜检查2002年和2013年之间。内镜检查后，既往未确诊的GERD患者被分为非糜烂性GERD（NERD）、糜烂性GERD（eGERD）或Barrett食管。H.结果：共纳入5156例胃食管反流病患者，其中NERD 1992例，eGERD 1392例，占65.6%。约1772例无反流和/或食管炎症状的消化不良患者作为对照。食管裂孔疝增加了eGERD和NERD的风险。eGERD在肥胖者中更常见（OR =1.72，p
Objective: Gastroesophageal reflux disease (GERD) and esophageal adenocarcinoma have been increasing. We studied the relationship of conventional risk factors and Helicobacter pylori infection in patients with erosive and non-erosive GERD and Barrett's esophagus.Materials and methods: This was a retrospective study of dyspeptic patients undergoing upper endoscopy between 2002 and 2013. Following endoscopy, those with previously undiagnosed GERD were sub-grouped into non-erosive GERD (NERD), erosive GERD (eGERD), or Barrett's esophagus. H. pylori status was confirmed by 2 positive tests.Results: About 5156 patients were included, GERD was present in 65.6% including 1992 with NERD and 1392 with eGERD. About 1772 dyspeptic patients without symptoms of reflux and/or esophagitis served as controls. A hiatal hernia increased the risk of both eGERD and NERD. eGERD was more prevalent among the obese (OR =1.72, p