A Pyrene‐Modified Serinol Nucleic Acid Nanostructure Converts the Chirality of Threoninol Nucleic Acids into Circularly Polarized Luminescence Signals
A Pyrene‐Modified Serinol Nucleic Acid Nanostructure Converts the Chirality of Threoninol Nucleic Acids into Circularly Polarized Luminescence Signals
复制标题
芘修饰的丝氨醇核酸纳米结构将苏氨醇核酸的手性转化为圆偏振发光信号
DOI：
10.1002/chem.202102333
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Asanuma Hiroyuki
中科院分区：
文献类型：
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作者：
Kashida Hiromu;Nishikawa Keiji;Ito Yuka;Murayama Keiji;Hayashi Ichiyo;Kakuta Takahiro;Ogoshi Tomoki;Asanuma Hiroyuki
本文报道了一种可响应核酸手性的圆偏振发光探针。通过含有芘修饰残基的对称丝氨醇核酸（SNA）的杂交制备非手性纳米结构。当添加与SNA互补的手性低聚物时，它们诱导SNA纳米线的螺旋性。当芘通过刚性炔基连接体连接到尿嘧啶碱基上时，观察到有效的圆二色性（CD）信号放大。观察到CPL和CD信号;它们依赖于添加的无环苏氨醇核酸（aTNA）寡聚体的手性。该系统可用于将手性生物分子的手性转化为手光信号。
Herein is reported a circularly polarized luminescent (CPL) probe that can respond to the chirality of nucleic acids. An achiral nanostructure was prepared by the hybridization of symmetric serinol nucleic acid (SNA) containing pyrene‐modified residues. When chiral oligomers that were complementary to the SNA were added, they induced helicity into the SNA nanowire. Efficient circular dichroism (CD) signal amplification was observed when pyrene was attached to uracil bases through a rigid alkynyl linker. Both CPL and CD signals were observed; they depended on the chirality of the added acyclic threoninol nucleic acid (aTNA) oligomer. This system can be used to convert the chirality of chiral biomolecules into chiroptical signals.