Spectrum of Parkinson's disease, Parkinson's dementia, and lewy body dementia
Spectrum of Parkinson's disease, Parkinson's dementia, and lewy body dementia
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DOI：
10.1016/s0733-8619(05)70230-9
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发表时间：
2000-11-01
影响因子：
2.4
通讯作者：
Burn, D
中科院分区：
文献类型：
--
作者：
McKeith, IG;Burn, D
痴呆症在帕金森病（PD）患者中比在年龄匹配的一般人群中更常见。PD中的痴呆可能是由各种潜在的病理过程和神经化学缺陷引起的皮质和皮质下痴呆综合征的混合物引起的。原发性痴呆综合征已被描述为与PD有几个共同的病理和临床特征。路易体痴呆（DLB）占老年痴呆综合征的15%至20%，其患病率仅次于阿尔茨海默病。PD和DLB中痴呆之间的关系尚未完全解决，但在神经病理学底物、临床特征和治疗反应方面可能被认为是有用的。
Dementia occurs more commonly in individuals with Parkinson's disease (PD) than in the age-matched general population. Dementia in PD may result from a mixture of cortical and subcortical dementia syndromes caused by a variety of underlying pathologic processes and neurochemical deficits. A primary dementia syndrome has been described that shares several pathologic and clinical characteristics with PD. Dementia with Lewy bodies (DLB) accounts for 15% to 20% of all dementia syndromes in old age, which makes it second only to Alzheimer's disease in prevalence. The relationship between dementia in PD and DLB has not been fully resolved but may be considered useful in terms of neuropathologic substrate, clinical features, and response to treatment.