Solubility and thermodynamic properties of baicalein in water and ethanol mixtures from 283.15 to 328.15 K
Solubility and thermodynamic properties of baicalein in water and ethanol mixtures from 283.15 to 328.15 K
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DOI：
10.1080/00986445.2019.1700116
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发表时间：
2019-12
影响因子：
2.5
通讯作者：
Fei Mo;Jialiang Ma;Peipei Zhang;Dawei Zhang;Huihui Fan;Xin Yang;Li Zhi;Jiye Zhang
中科院分区：
文献类型：
--
作者：
Fei Mo;Jialiang Ma;Peipei Zhang;Dawei Zhang;Huihui Fan;Xin Yang;Li Zhi;Jiye Zhang
摘要黄芩素是一种具有抗炎、抗病原体、抗肿瘤和神经保护等多种药理作用的中药。但是，由于其在水溶液中的溶解度有限且稳定性差，其临床应用受到很大影响。本文研究了黄芩素在283.15 ~ 328.15 K（实验室和制药行业常用温度）水-乙醇二元体系中的溶解度和热力学性质，以优化黄芩素的提取和纯化工艺。结果表明，黄芩素的实验溶解度随二元体系中乙醇比例的增加和温度的升高而增加。选用理想混合物模型、多项式经验方程、Apelblat方程、Buchowski-Ksiazczak（λh）方程、一般单一模型以及Jouyban-Acree和van't霍夫组合模型等6种模型对实验数据进行关联。通用单一模型的关联结果与实验测得的溶解度数据吻合较好，均方根偏差（%）在0.22-1.06之间。此外，其热力学性质表明，黄芩素在所研究条件下的溶解过程是一个非自发的吸热过程。
Abstract Baicalein is a traditional Chinese medicine with multiple pharmacological effects, including anti-inflammatory activity, anti-pathogen activity, antitumor activity and neuroprotective activity. However, due to the limited solubility and poor stability in aqueous solution, its clinical application is greatly compromised. Here, we investigated the solubility and thermodynamic properties of baicalein in a binary system of water and ethanol from 283.15 K to 328.15 K (common temperature in labs and pharmaceutical industry), in order to optimize the extraction and purification process of baicalein. The results showed that the experimental solubility of baicalein increased with the increased ethanol ratio in the binary system and with the rising temperature. Six models, the ideal mixture model, the polynomial empirical equation, the Apelblat equation, the Buchowski–Ksiazczak (λh) equation, the general single model and the combination of Jouyban–Acree and van’t Hoff models, were chosen to correlate with the experimental data. The correlated results of the general single model were in good agreement with the experimentally measured solubility data with root mean square deviations (%) in the range of 0.22–1.06 In addition, its thermodynamic property implied that the dissolution process of baicalein under the studied conditions is a non-spontaneous endothermic process.