Assessment of Subclinical Let Ventricular Dysfunction in Aortic Stenosis
Assessment of Subclinical Let Ventricular Dysfunction in Aortic Stenosis
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DOI：
10.1016/j.jcmg.2018.08.040
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发表时间：
2019-01-01
影响因子：
14
通讯作者：
Marwick, Thomas H.
中科院分区：
文献类型：
--
作者：
Dahl, Jordi S.;Magne, Julien;Marwick, Thomas H.
左心室（LV）收缩功能障碍是严重主动脉瓣狭窄（AS）压力超负荷的不良后果。间质间隙扩大伴反应性纤维化，随后伴置换纤维化和细胞死亡，已被认为是转变为症状、心力衰竭和不良心血管事件的主要驱动因素，即使在主动脉瓣置换术（AVR）后也是如此。早期和准确识别心肌功能不全为优化严重AS的干预时机提供了可能。在无症状患者中，LV射血分数（EF）临界点为
Left ventricular (LV) systolic dysfunction is an adverse consequence of the pressure overload of severe aortic stenosis (AS). The enlargement of the interstitial space with reactive fibrosis and subsequently with replacement fibrosis and cell death has been suggested to be the main driver of the transition to symptoms, heart failure, and adverse cardiovascular events even after aortic valve replacement (AVR). Early and accurate recognition of myocardial dysfunction offers the potential to optimize the timing of intervention in severe AS. In the asymptomatic patient, an LV ejection fraction (EF) cutpoint of