Brain glucose metabolism in eating disorders assessed by positron emission tomography.
Brain glucose metabolism in eating disorders assessed by positron emission tomography.
复制标题
通过正电子发射断层扫描评估饮食失调中的脑葡萄糖代谢。
DOI：
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发表时间：
1995
影响因子：
5.5
通讯作者：
F. Lotstra
中科院分区：
文献类型：
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作者：
V. Delvenne;S. Goldman;V. Maertelaer;A. Luxen;J. Mendlewicz;F. Lotstra
目的
由于厌食症和贪食症患者表现出相似的临床和神经生物学症状，本研究的目的是比较这些患者静息时的脑葡萄糖代谢。
方法
正电子发射断层扫描（18-F）-氟脱氧葡萄糖被用来评估脑葡萄糖代谢（CMRglu）在10名体重正常的暴食症妇女，在10名体重不足的厌食症患者，并在10名年龄和性别匹配的健康志愿者。
结果
厌食症患者与贪食症患者和对照组相比，大脑皮质葡萄糖的绝对活性显著降低。厌食症患者与正常对照组相比，也表现出较高的相对CMRglu在下额叶皮层和基底神经节，壳核和尾状核相对高代谢相比，贪食症患者。因此，两个进食障碍组与对照组相比，顶叶葡萄糖的相对值较低。
讨论
虽然绝对全球代谢似乎与体重减轻有关，但我们可以假设饮食失调中常见的顶叶皮质功能障碍，或者该皮质对饮食失调的后果特别敏感。
OBJECTIVE
As anorectic and bulimic patients present similar clinical and neurobiological symptoms, the purpose of this study was to compare brain glucose metabolism at rest in these patients.
METHODS
Positron emission tomography with (18-F)-fluorodeoxyglucose was used to evaluate cerebral glucose metabolism (CMRglu) in 10 normal-weight bulimic women, in 10 underweight anorectic patients, and in 10 age- and sex-matched healthy volunteers.
RESULTS
Absolute global cortical glucose activity was significantly lower in anorectic patients compared with bulimic and control subjects. Anorectic patients compared with normal control subjects also showed higher relative CMRglu in the inferior frontal cortex and in the basal ganglia, and putamen and caudate relative hypermetabolism when compared with bulimic patients. Thus, both eating disorder groups differed from control subjects in low relative parietal values of glucose.
DISCUSSION
While absolute global metabolism seems to be related to weight loss, we can hypothesize either a common parietal cortex dysfunction in eating disorders or a particular sensitivity of this cortex to consequences of eating disturbances.