Podophyllotoxin Derivatives Show Activity against Brontispa Longissima Larvae
Podophyllotoxin Derivatives Show Activity against Brontispa Longissima Larvae
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DOI：
10.1177/1934578x1000500820
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发表时间：
2010-01
影响因子：
1.8
通讯作者：
Jing Zhang;Ying-Qian Liu;Liu Yang;Gang Feng
中科院分区：
文献类型：
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作者：
Jing Zhang;Ying-Qian Liu;Liu Yang;Gang Feng
为了寻找生物合理的杀虫剂，首次测试了十一种鬼臼毒素类似物对长叶椰心五龄幼虫的体内杀虫活性。在所有测试的化合物中，脱氧鬼臼毒素 (3) 和 β-鬼臼苦素 (4) 比川楝素（一种从楝树中提取的商业杀虫剂）表现出更有前景和更显着的杀虫活性，并且已揭示了重要的 SAR 信息。总之，这些初步结果可能有助于指导鬼臼毒素的进一步修饰，以开发潜在的新型杀虫剂。
In an attempt to find biorational insecticides, eleven podophyllotoxin analogues were tested for their insecticidal activity against the fifth-instar larvae of Brontispa longissima in vivo for the first time. Among all of the tested compounds, deoxypodophyllotoxin (3) and β-apopicropodophyllin (4) showed more promising and pronounced insecticidal activity than toosendanin, a commercial insecticide derived from Melia toosendan, and important SAR information has been revealed. Together, these preliminary results may be useful in guiding further modification of podophyllotoxins in the development of potential new insecticides.