Oxytocin administration modulates the complex type of ultrasonic vocalisation of mice pups prenatally exposed to valproic acid
Oxytocin administration modulates the complex type of ultrasonic vocalisation of mice pups prenatally exposed to valproic acid
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催产素的施用调节了产前暴露于丙戊酸的幼鼠的复杂类型的超声波发声
DOI：
10.1016/j.neulet.2021.135985
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发表时间：
2021
影响因子：
2.5
通讯作者：
Tsuji Chiharu
中科院分区：
文献类型：
--
作者：
Tsuji Takahiro;Mizutani Ryuko;Minami Kana;Furuhara Kazumi;Fujisaku Tomoaki;Pinyue Fu;Jing Zhong;Tsuji Chiharu
自闭症谱系障碍（ASD）是一种神经发育障碍，其特征是交流障碍，没有治愈性治疗。母体分离诱导的超声波发声（USV）被广泛用于评估幼崽和母鼠之间的沟通障碍。特别地，许多遗传修饰的ASD模型小鼠中的USV呼叫被改变。之前，我们证明了在子宫内暴露于丙戊酸的小鼠幼仔（VPA幼仔）在出生后第11天显示USV呼叫数量减少，并通过皮下注射催产素进行拯救。然而，在VPA幼仔中尚未评价催产素引起的USV叫声的质的变化。在本研究中，我们研究了催产素效应的持续时间，并分析了使用VPA幼崽的USV呼叫模式的改变。催产素给药增加了USV呼叫的总数，并且在VPA幼仔中效果持续长达120分钟。模式分析表明，复杂叫声的增加也持续到120分钟。这些结果表明，催产素对VPA幼仔的USV叫声，主要是复杂的叫声，有延长的作用，表明催产素可以恢复它们对母亲分离的社会模式。
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterised by communication disability with no curative treatment. Maternal separation-induced ultrasonic vocalisation (USV) was widely used to assess communication disability between pups and dams. Particularly, USV calls in many genetically modified ASD model mice were altered. Previously, we demonstrated that mice pups exposed to valproic acid in utero (VPA pups) showed decreased number of USV calls on postnatal day 11 and were rescued by subcutaneous injection of oxytocin. However, the qualitative change of USV calls by oxytocin has not been evaluated in VPA pups. In the present study, we examined the duration of oxytocin effect and analysed the altered pattern of USV calls using VPA pups. The oxytocin administration increased the total number of USV calls and the effect persisted up to 120 min in VPA pups. The pattern analysis revealed that the increase in the number ofcomplexcalls also persisted up to 120 min. These results suggested that oxytocin had a prolonged effect on USV calls, mainly oncomplexcalls, in VPA pup, showing that oxytocin could recover their social modality to respond to maternal separation.