SERUM ULTRAFILTERABLE COPPER, TOTAL COPPER AND CERULOPLASMIN CONCENTRATIONS IN GYNECOLOGICAL CARCINOMAS
SERUM ULTRAFILTERABLE COPPER, TOTAL COPPER AND CERULOPLASMIN CONCENTRATIONS IN GYNECOLOGICAL CARCINOMAS
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DOI：
10.1177/000456329303000603
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发表时间：
1993-11-01
影响因子：
2.2
通讯作者：
ARUMANAYAGAM, M
中科院分区：
文献类型：
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作者：
CHAN, A;WONG, F;ARUMANAYAGAM, M
血清铜和铜蓝蛋白浓度在各种癌症中均升高，但尚不清楚血清铜的升高是单独由铜蓝蛋白升高引起，还是由“游离”铜升高引起。因此，我们确定了超滤铜来回答这个问题。使用 Amicon 微分配系统制备血清超滤液，并通过无焰原子吸收分光光度法测定超滤（游离）铜。血清总铜采用火焰原子吸收光谱法测定，铜蓝蛋白采用速率比浊法测定。妇科肿瘤患者和对照受试者之间的超滤铜浓度没有显着差异。然而，与对照组相比，癌症患者的总铜和铜蓝蛋白浓度显着升高。与总铜和铜蓝蛋白浓度相反，超滤铜浓度没有显示出随着癌症阶段的增加而显着增加。
Serum copper and caeruloplasmin concentrations are elevated in various carcinomas, but it is not known whether the rise in serum copper is due to elevation of caeruloplasmin alone or whether it is also due to the elevation of 'free' copper. We therefore determined ultrafiltrable copper to answer this question. Serum ultrafiltrate was prepared using the Amicon micropartition system and ultrafiltrable (free) copper was determined by flameless atomic absorption spectrophotometry. Serum total copper was determined by flame atomic absorption spectrometry and caeruloplasmin by rate nephelometry. There was no significant difference in the ultrafiltrable copper concentration between patients with gynaecological tumours and control subjects. However, total copper and caeruloplasmin concentrations were significantly elevated in cancer patients compared with control subjects. In contrast to total copper and caeruloplasmin concentrations, ultrafiltrable copper concentrations showed no significant increase with increase in the stage of the cancer.