RECKing MMP function: implications for cancer development
RECKing MMP function: implications for cancer development
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DOI：
10.1016/s0962-8924(02)02280-8
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发表时间：
2002-05-01
影响因子：
19
通讯作者：
Coussens, LM
中科院分区：
文献类型：
--
作者：
Rhee, JS;Coussens, LM
癌症是一个多阶段的过程，需要肿瘤细胞和反应性基质细胞发生渐进的遗传和表观遗传变化。恶性进展过程中发生的许多改变是由细胞外蛋白酶的基质金属蛋白酶（MMP）家族及其内源性抑制剂调节的。最近的工作发现了一种新的 MMP 细胞表面抑制剂 - RECK。 RECK 在胚胎发生和肿瘤发生过程中调节 MMP 诱导的细胞周信号级联。 RECK 的纯合性缺失会导致胚胎致死并减弱成人肿瘤的发展，从而为蛋白酶抑制剂作为抗癌治疗的有效作用提供了进一步的支持。
Cancer is a multistage process requiring progressive genetic and epigenetic changes in neoplastic and responding stromal cells. Many alterations that occur during the process of malignant progression are regulated by the matrix metalloproteinase (MMP) family of extracellular proteases and their endogenous inhibitors. Recent work has identified a new cell-surface inhibitor of MMPs - RECK. RECK regulates MMP-induced pericellular signaling cascades during embryogenesis and tumorigenesis. Homozygous loss of RECK results in embryonic lethality and attenuated tumor development in adults thus providing further support for an efficacious role for protease inhibitors as anticancer therapeutics.