A Twin Study of ADHD Symptoms in Early Adolescence: Hyperactivity-impulsivity and Inattentiveness Show Substantial Genetic Overlap but Also Genetic Specificity
A Twin Study of ADHD Symptoms in Early Adolescence: Hyperactivity-impulsivity and Inattentiveness Show Substantial Genetic Overlap but Also Genetic Specificity
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DOI：
10.1007/s10802-010-9451-9
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发表时间：
2011-02-01
影响因子：
3.6
通讯作者：
Plomin, Robert
中科院分区：
文献类型：
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作者：
Greven, Corina U.;Rijsdijk, Fruehling V.;Plomin, Robert
该杂志之前的一篇论文揭示了从英国代表性人群样本中抽取的8岁双胞胎样本中多动症-冲动性和注意力不集中维度之间的大量遗传重叠。四年后，当双胞胎12岁时，从同一样本中抽取的5,500多对双胞胎再次在基于DSM-IV的修订Conners父母评定量表上进行评级，以评估ADHD两个维度的症状。多动-冲动和注意力不集中的遗传率都很高（约70%），缺乏病因性别差异的证据。关键的发现是0.55的遗传相关性，表明多动-冲动和注意力不集中在很大程度上受到相同基因的影响，但这两个维度也显示出巨大而显著的独特遗传效应。这些在青春期早期的结果证实了我们在童年中期的发现，为ADHD维度的大量遗传重叠和遗传异质性提供了证据。未来的遗传研究应单独调查ADHD的各个方面。
A previous paper in this journal revealed substantial genetic overlap between the ADHD dimensions of hyperactivity-impulsivity and inattentiveness in a sample of 8-year old twins drawn from a UK-representative population sample. Four years later, when the twins were 12 years old, more than 5,500 pairs drawn from the same sample were rated again on the DSM-IV based Revised Conners' Parent Rating Scale to assess symptoms on both ADHD dimensions. Heritabilities were high (around 70%) for both hyperactivity-impulsivity and inattentiveness and evidence for etiological sex differences was absent. The critical finding was a genetic correlation of 0.55, indicating that hyperactivity-impulsivity and inattentiveness are substantially influenced by the same genes but that the two dimensions also show large and significant unique genetic effects. These results in early adolescence confirm our findings in middle childhood, providing evidence for substantial genetic overlap as well as genetic heterogeneity of the ADHD dimensions. Future genetic studies should investigate the ADHD dimensions separately.