Comparison of the different kinds of feeding on the level of fecal calprotectin
Comparison of the different kinds of feeding on the level of fecal calprotectin
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不同饲喂方式对粪便钙卫蛋白水平的比较
DOI：
10.1016/j.earlhumdev.2014.06.005
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发表时间：
2014-09-01
影响因子：
2.5
通讯作者：
Sheng, Xiaoyang
中科院分区：
文献类型：
--
作者：
Li, Feng;Ma, Jingqiu;Sheng, Xiaoyang
工作背景：有争议的结果已被报道的影响类型的喂养对粪便钙卫蛋白在infants.Objective：为了评估粪便钙卫蛋白水平在母乳喂养或nonbreast喂养的健康infants.Design：一项研究进行了比较粪便钙卫蛋白在婴儿谁是纯母乳喂养相比，那些谁没有母乳喂养在上海，中国。采集并分析粪便样本，并使用市售酶联免疫吸附试验测定粪便钙卫蛋白浓度。测量了婴儿的体重和身长。父母被要求填写一份简短的问卷，与几个临床和社会人口学factors.Subjects的问题：本研究包括105名健康婴儿年龄0-5 months.Results：粪便样本来自105名健康婴儿（63名男孩，42名女孩），中位年龄为2.86个月（范围1-5.88）。母乳喂养婴儿的粪便钙卫蛋白浓度中位数显著高于（377 μ g/g，范围35-937 μ g/g）高于非母乳喂养的（233微克/克，范围37-895微克/克）（p = 0.001）。发现从0到5个月，粪钙卫蛋白与年龄呈显著负相关（母乳喂养：斯皮尔曼rho-0.346，p = 0.010;非母乳喂养：斯皮尔曼rho-0.478，p < 0.001）。我们的研究结果表明，喂养方式影响粪便中钙卫蛋白的浓度，母乳喂养的婴儿比非母乳喂养的婴儿有更高的水平在生命的最初几个月。这可能表明人乳通过免疫调节因子影响肠粘膜。(C)2014爱思唯尔爱尔兰有限公司版权所有。
Background: Controversial results have been reported on the effect of type of feeding on the level of fecal calprotectin in infants.Objective: To assess fecal calprotectin levels in breast fed or nonbreast fed healthy infants.Design: A study was conducted to compare fecal calprotectin in infants who were exclusively breastfed compared to those who were not breastfed in Shanghai, China. Stool samples were collected and analyzed, and the fecal calprotectin concentration was determined using a commercially available enzyme-linked immunosorbent assay. The infant's weight and length were measured. Parents were asked to fill in a brief questionnaire, with questions about several clinical and sociodemographic factors.Subjects: This study included 105 healthy infants aged 0-5 months.Results: Stool samples were obtained from 105 healthy infants (63 boys, 42 girls) with a median age of 2.86 months (range 1-5.88). The median fecal calprotectin concentration was significantly higher in breast fed infants (377 mu g/g, range 35-937 mu g/g) than that in nonbreast fed ones (233 mu g/g, range 37-895 mu g/g) (p = 0.001).A correlation was found that from 0 to 5 months, fecal calprotectin was negatively and significantly associated with age in both two kinds of feeding (breast fed: Spearman's rho -0.346, p = 0.010; nonbreast fed: Spearman's rho -0.478, p < 0.001).Conclusions: Our findings show that the kind of feeding influences the fecal calprotectin concentration and breast fed infants have higher levels than nonbreast fed ones in the first months of life. This may represent that human milk influences the gut mucosa by immunomodulating factors. (C) 2014 Elsevier Ireland Ltd. All rights reserved.