Formation of the dimethylbenzimidazole ligand of coenzyme B12 under physiological conditions by a facile oxidative cascade
Formation of the dimethylbenzimidazole ligand of coenzyme B12 under physiological conditions by a facile oxidative cascade
复制标题
DOI：
10.1021/ol034530m
复制
发表时间：
2003-06-26
期刊：
影响因子：
5.2
通讯作者：
Begley, TP
中科院分区：
文献类型：
--
作者：
Maggio-Hall, LA;Dorrestein, PC;Begley, TP
Dimethylbezimidazole, the axial ligand of vitamin B-12, is synthesized from riboflavin by a two-electron oxidation, a retro-aldol condensation, and a second two-electron oxidation. This oxidative cascade readily takes place nonenzymatically under physiological conditions.
