Effect of adipose tissue-derived inflammatory and proangiogenic cytokines on proliferative diabetic retinopathy
Effect of adipose tissue-derived inflammatory and proangiogenic cytokines on proliferative diabetic retinopathy
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发表时间：
2014
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通讯作者：
D. Aban;S. Tan;B. Eldem;S. Karahan
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作者：
D. Aban;S. Tan;B. Eldem;S. Karahan
目的：目的检测增生性糖尿病视网膜病变（PDR）患者玻璃体及血清中TNF-α、IL-6、VEGF、IL-1β、IL-8、IL-17、MCP-1、IL-1 Ra、IL-10的浓度，探讨脂肪组织在PDR发病中的作用。方法：对22例PDR患者进行前瞻性评价。7例尸体和11例特发性视网膜前膜或黄斑裂孔患者作为对照。采用多重珠阵列技术来评估细胞因子的浓度。结果：PDR组玻璃体腔内VEGF、IL-8、IL-6水平明显高于对照组。PDR组玻璃体内IL-17、IL-8、IL-6水平明显升高，而IL-10、IL-1 Ra水平明显低于血清水平。糖尿病患者的细胞因子水平与体重指数（BMI）、空腹血糖（FBG）和糖化血红蛋白（HbA 1c）无显著相关性。结论：在PDR中，玻璃体内促炎性和抗炎性脂肪细胞因子之间的平衡被破坏，有利于玻璃体液中的促炎性和促血管生成细胞因子。本研究支持脂肪细胞因子在PDR血管病理中的作用。PDR似乎是一种局部炎症性疾病。然而，肥胖可能不是PDR炎症介质的根源。
Objective: To determine the vitreous and serum concentrations of TNF-α, IL-6, VEGF, IL-1β, IL-8, IL-17, MCP-1, IL-1Ra, IL-10 in patients with proliferative diabetic retinopathy (PDR) and to investigate the effect of adipose tissue on the pathogenesis of PDR. Methods: Twenty-two patients with PDR were prospectively evaluated. Seven cadavers and 11 patients with idiopathic epiretinal membrane or macular hole served as the controls. Multiplex bead array technology was employed to assess the concentrations of the cytokines. Results: The intravitreal levels of VEGF, IL-8, IL-6 were significantly higher in PDR group than control groups. In PDR group, the levels of IL-17, IL-8, IL-6 were significantly elevated in the vitreous, whereas the intravitreal levels of IL-10, IL-1Ra were found to be significantly lower than the serum concentrations. No significant correlation was found between cytokine levels and body mass index (BMI), fasting blood glucose (FBG), or glycated haemoglobin (HbA1c) of diabetic patients. Conclusion: In PDR the balance between the intravitreal pro- and anti- inflammatory adipocytokines is disturbed in favor of proinflammatory and proangiogenic cytokines in the vitreous humour. This study supports the role of adipocytokines in vascular pathology in PDR. It seems that PDR is a local inflammatory disease. However, obesity may not be the root of the inflammatory mediators in PDR.