CHANGES IN CONDUCTION VELOCITY AND FIBRE SIZE PROXIMAL TO PERIPHERAL NERVE LESIONS
CHANGES IN CONDUCTION VELOCITY AND FIBRE SIZE PROXIMAL TO PERIPHERAL NERVE LESIONS
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DOI：
10.1113/jphysiol.1961.sp006724
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发表时间：
1961-01-01
影响因子：
5.5
通讯作者：
THOMAS, PK
中科院分区：
文献类型：
--
作者：
CRAGG, BG;THOMAS, PK
在7-446天前，对家兔腓神经远端进行挤压、缩窄、切断、剥离或切断、撕脱等损伤，测量其近端腓神经的传导速度、轴突直径和总纤维直径。在前三种类型的损伤后，传导速度福尔斯在25-30天内降至正常的90%，并在50-100天内进一步降至正常的80%。这种减少一直维持到150天，但大多数神经在200天恢复正常速度，此后保持正常。当神经远端撕脱时，神经瘤上方的传导速度在损伤后200-400天福尔斯到正常的60-70%，并且没有恢复的迹象。在所有四种类型的损伤后，损伤上方最大纤维的轴突直径平均减少到正常的85.9%，在损伤后50-150天内，总纤维直径平均减少到正常的89.8%。前三种类型损伤后150天轴突和总纤维直径增加，225天基本恢复正常。在神经远端撕脱后，从损伤后200至400天，最大的近端纤维显示出直径进一步减小，总纤维直径和轴突直径大致相等地减小。
Conduction velocity, azon diameter and total fibre diameter have been measured in the peroneal nerves of rabbits proximal to lesions produced by crushing, constricting, cutting and suturing or cutting and avulsing the distal end of the nerve, 7-446 days previously. After the first three types of injury conduction velocity falls to 90% of normal within 25-30 days, and is further reduced to 80% of normal within 50-100 days. This reduction is maintained until 150 days, but most nerves recover normal velocities by 200 days and remain normal thereafter. When the distal end of the nerve is avulsed, conduction velocity above the consequent neuroma falls to 60-70% of the normal 200-400 days after injury and shows no sign of recovery. After all four types of injury a reduction of axon diameter in the largest fibres above the injury to an average of 85.9% of normal tends to precede an overlapping reduction of total fibre diameter to an average of 89.8% of normal in the period 50-150 days after injury. For the first three types axon and total fibre diameter increase after 150 days and return to near normal by 225 days after injury. After avulsion of the distal end of the nerve, from 200 to 400 days after injury the largest proximal fibres show further reduction in diameter, total fibre diameter and axon diameter being reduced approximately equally.