Human genomic characterization of a novel locus-specific repetitive sequence.
Human genomic characterization of a novel locus-specific repetitive sequence.
复制标题
新型位点特异性重复序列的人类基因组表征。
DOI：
10.1006/geno.1995.9989
复制
发表时间：
1995
期刊：
影响因子：
--
通讯作者：
Ruano,G
中科院分区：
文献类型：
--
作者：
Li,WL;Huckaby,CS;Kouri,RE;Ruano,G
利用任意PCR技术鉴定并表征了一种新的人类染色体位点特异性重复序列。重复单体共有序列长100 bp，每个单倍体人类基因组至少有140至160个重复序列拷贝。重复序列高度聚集在20 q12上的200- 400-kb区域内。高度多态性重复序列以稳定的孟德尔方式遗传。杂交分析显示，只有在类人猿和旧大陆的猴子，重复的安排也是多态性的重复元件可检测的保护。
A novel human chromosome locus-specific repetitive sequence was identified and characterized using arbitrary PCR. The repeat monomer consensus sequence is 100 bp long, and there are a minimum of 140 to 160 copies of the repetitive sequence per haploid human genome. The repetitive sequence is highly clustered on 20q12 within a 200- to 400-kb region. The highly polymorphic repeat array is inherited in a stable Mendelian fashion. Hybridization analysis revealed detectable conservation of the repeated element only among hominoids and Old World monkeys, where repeat arrangements are also polymorphic.