Mechanical property changes during neonatal development and healing using a multiple regression model
Mechanical property changes during neonatal development and healing using a multiple regression model
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DOI：
10.1016/j.jbiomech.2012.01.030
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发表时间：
2012-04-30
影响因子：
2.4
通讯作者：
Soslowsky, Louis J.
中科院分区：
文献类型：
--
作者：
Ansorge, Heather L.;Adams, Sheila;Soslowsky, Louis J.
在新生儿发育过程中，肌腱经历了一个精心安排的过程，在此过程中，广泛的结构和成分变化同步发生，以产生正常组织。相反，在损伤的修复反应中，结构和成分发生变化，但产生机械下肌腱。因此，发育过程被假设为阐明机制洞察力的潜在范例，需要开发治疗方式来改善成人组织愈合。本研究的目的是比较和对比正常发育和损伤在早期和晚期发育愈合。采用反向多元线性回归，定量客观地反映了肌腱的结构-功能关系。具体来说，蛋白聚糖被证明是早期发育愈合中模量的重要预测因子，而不是晚期发育愈合或正常发育中的模量预测因子。多个独立参数预测正常发育期间的松弛百分比，然而，只有biglycan和纤维直径参数预测早期发育愈合期间的松弛百分比。最后，在早期发育和早期发育愈合之间观察到多种差异预测因素；然而，在晚期发育和晚期发育愈合之间没有观察到差异预测因素。本研究提出了一个模型，通过该模型，客观分析如何影响力学参数发展的成分和结构参数可以定量测量。此外，本研究的信息可用于开发新的治疗方法，从而改善成人肌腱的愈合。(C) 2012 Elsevier Ltd.版权所有。
During neonatal development, tendons undergo a well orchestrated process whereby extensive structural and compositional changes occur in synchrony to produce a normal tissue. Conversely, during the repair response to injury, structural and compositional changes occur, but a mechanically inferior tendon is produced. As a result, developmental processes have been postulated as a potential paradigm for elucidation of mechanistic insight required to develop treatment modalities to improve adult tissue healing. The objective of this study was to compare and contrast normal development with injury during early and late developmental healing. Using backwards multiple linear regressions, quantitative and objective information was obtained into the structure-function relationships in tendon. Specifically, proteoglycans were shown to be significant predictors of modulus during early developmental healing but not during late developmental healing or normal development. Multiple independent parameters predicted percent relaxation during normal development, however, only biglycan and fibril diameter parameters predicted percent relaxation during early developmental healing. Lastly, multiple differential predictors were observed between early development and early developmental healing; however, no differential predictors were observed between late development and late developmental healing. This study presents a model through which objective analysis of how compositional and structural parameters that affect the development of mechanical parameters can be quantitatively measured. In addition, information from this study can be used to develop new treatment and therapies through which improved adult tendon healing can be obtained. (C) 2012 Elsevier Ltd. All rights reserved.