The discovery value of "big science"
The discovery value of "big science"
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DOI：
10.1084/jem.20070073
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发表时间：
2007-04-16
影响因子：
15.3
通讯作者：
Yamada, Tadataka
中科院分区：
文献类型：
--
作者：
Esparza, Jose;Yamada, Tadataka
生物医学研究的日益复杂性促使人们探索大规模合作研究的新模式。然而，这种大科学的方法已经造成了焦虑和潜在的紧张局势之间的研究者驱动的研究，和研究的指导下，一个更有组织的，合作的努力。另一个潜在的紧张关系存在于纯粹为寻求新知识而进行的研究与旨在找到解决办法的研究之间。我们认为，大生物医学-协调的多学科小组的工作，使用最新的技术来解决复杂的问题，可以是一个重要的方式来利用个人的创造力的研究人员，刺激创新，并提供基础设施，实验系统，和资源需要解决我们的全球社会面临的紧迫的健康问题。我们以全球艾滋病毒疫苗企业为例进行讨论。
The increasing complexity of biomedical research is leading to the exploration of new models for large-scale collaborative research. This Big Science approach, however, has created anxieties and potential tensions between investigator-driven research, and research guided by a more organized, collaborative effort. Another potential tension exists between research conducted purely in search of new knowledge and research aimed at finding solutions. We argue that big biomedicine-the work of coordinated multidisciplinary groups that use the latest technologies to solve complex problems can be an important way to harness the creativity of individual investigators, stimulate innovation, and supply the infrastructure, experimental systems, and resources needed to solve the urgent health problems confronted by our global society. We discuss this using the example of the Global HIV Vaccine Enterprise.