Stress-Induced Mutagenesis.
Stress-Induced Mutagenesis.
复制标题
DOI：
10.1128/ecosalplus.7.2.3
复制
发表时间：
2012-11
期刊：
影响因子：
--
通讯作者：
Foster PL
中科院分区：
文献类型：
--
作者：
Williams AB;Foster PL
对突变起源和机制的早期研究导致了这样一种教条的建立：在没有外力的情况下，自发突变率是恒定的。然而，最近来自各种实验系统的结果表明，突变率可以随着选择压力的增加而增加。本章总结的数据表明，在压力条件下，大肠杆菌和沙门氏菌通过调节其基因变化的潜力来增加有益突变的可能性。讨论了几种用于研究应力诱导诱变的实验系统，特别强调了用于“适应性突变”的福斯特-凯恩斯系统。coliandSalmonella。从其他模型系统的例子说明，应激诱导诱变是一种自然和普遍的现象，并不局限于肠道细菌。最后，对胁迫诱变研究中存在的一些争议进行了总结和讨论，并对胁迫诱变研究现状进行了展望。
Early research on the origins and mechanisms of mutation led to the establishment of the dogma that, in the absence of external forces, spontaneous mutation rates are constant. However, recent results from a variety of experimental systems suggest that mutation rates can increase in response to selective pressures. This chapter summarizes data demonstrating that,under stressful conditions,Escherichia coliandSalmonellacan increase the likelihood of beneficial mutations by modulating their potential for genetic change.Several experimental systems used to study stress-induced mutagenesis are discussed, with special emphasison the Foster-Cairns system for "adaptive mutation" inE. coliandSalmonella. Examples from other model systems are given to illustrate that stress-induced mutagenesis is a natural and general phenomenon that is not confined to enteric bacteria. Finally, some of the controversy in the field of stress-induced mutagenesis is summarized and discussed, and a perspective on the current state of the field is provided.