Effects of pulsed electromagnetic fields on learning and memory abilities of STZ-induced dementia rats
Effects of pulsed electromagnetic fields on learning and memory abilities of STZ-induced dementia rats
复制标题
脉冲电磁场对STZ致痴呆大鼠学习记忆能力的影响
DOI：
10.1080/15368378.2019.1591437
复制
发表时间：
2019
影响因子：
1.7
通讯作者：
Pan Weidong
中科院分区：
文献类型：
--
作者：
Li Yue;Zhang Yingchao;Wang Weihong;Zhang Yuxia;Yu Yang;Cheing Gladys Lai Ying;Pan Weidong
摘要引言：最近的研究表明，脉冲电磁场（EMF）具有治疗痴呆的潜力，但相关的神经生物学效应尚不清楚。方法：将40只SD大鼠随机分为4组：对照组、假手术组、STZ组和STZ + MF组。Morris水迷宫检测大鼠学习记忆能力。用定量PCR法检测胰岛素生长因子1和2（IGF-1和IGF-2）基因表达。结果：STZ致痴呆大鼠在脉冲电磁场作用下，其逃避潜伏期平均缩短66%。与STZ组相比，STZ + MF组游泳距离和首次通过平台时间分别减少55%和41.6%。此外，IGF-2基因表达与STZ组相比显著增加。结论：研究结果表明，脉冲电磁场暴露能改善STZ诱导的痴呆大鼠的学习记忆能力，这种作用可能与IGF信号转导过程有关，提示脉冲电磁场可能具有改善认知功能障碍的作用。
ABSTRACT Introduction: Recent studies have shown that pulsed electromagnetic field (EMF) has therapeutic potential for dementia, but the associated neurobiological effects are unclear. This study aimed to determine the effects of pulsed EMF on Streptozotocin (STZ)-induced dementia rats.Methods: Forty Sprague-Dawley rats were randomly allocated to one of the four groups: (i) control, (ii) normal saline injection (sham group), (iii) STZ injection (STZ group) and (iv) STZ injection with pulsed EMF exposure (PEMF, 10 mT at 20 Hz) (STZ + MF group). Morris water maze was used to assess the learning and memory abilities. Insulin growth factors 1 and 2 (IGF-1 and IGF-2) gene expression were determined by quantitative PCR. Results: The results showed that the mean escape latency in STZ-induced dementia rats was reduced by 66% under the exposure of pulsed EMF. Compared with the STZ group, the swimming distance and the time for first crossing the platform decreased by 55 and 41.6% in STZ + MF group, respectively. Furthermore, the IGF-2 gene expression significantly increased compared to that of the STZ group. Conclusions: Our findings indicate that the pulsed EMF exposure can improve the ability of learning and memory in STZ-induced dementia rats and this effect may be related to the process of IGF signal transduction, suggesting a potential role for the pulsed EMF for the amelioration of cognition impairment.