Further evidence for a QTL influencing body mass index on chromosome 7p from a genome-wide scan in Dutch families
Further evidence for a QTL influencing body mass index on chromosome 7p from a genome-wide scan in Dutch families
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DOI：
10.1375/136905204323016177
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发表时间：
2004-04-01
期刊：
影响因子：
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通讯作者：
Boomsma, DI
中科院分区：
文献类型：
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作者：
Heijmans, BT;Beem, AL;Boomsma, DI
由于高热量饮食和久坐不动的生活方式的增加，肥胖对公共健康的威胁正在迅速增加。在这种环境下，基因影响可能在很大程度上决定肥胖相关特征的个体间差异。为了定位与体重调节相关的基因，我们对192个荷兰家庭进行了体重指数(BMI)的全基因组连锁扫描，BMI是衡量身体总脂肪的可靠指标，其中包括315个双胞胎和210个兄弟姐妹。经方差成分连锁分析，在6p25.1(LOD-Score，2.13)和7p21.1(LOD-Score，2.40)上观察到LOD-Score>2的区域。在第3、13、15和21号染色体上发现LOD-Score>1。值得注意的是，之前从墨西哥裔美国人、亚洲人和尼日利亚人等不同人群中获得了7P上BMI假定的数量性状基因座的证据，这表明潜在基因可能在不同的环境中影响体重调节。7P连锁区的一个明显的候选位置是编码神经肽Y(NPY)的基因，它控制饱腹感和食物摄入量。
Obesity is a rapidly growing threat to public health, driven by the increased occurrence of high caloric diets and sedentary lifestyles. Within this environment, genetic influences may largely determine inter-individual differences in obesity-related traits. To map genes involved in weight regulation, we performed a genome-wide linkage scan for body mass index (BMI), a reliable measure of total body fat, in 192 Dutch families including 315 twins and 210 siblings with data on BMI. Using variance components linkage analysis, regions with LOD-scores greater than 2 were observed on 6p25.1 (LOD-score, 2.13) and 7p21.1 (LOD-score, 2.40). LOD-scores higher than 1 were found on chromosomes 3, 13, 15 and 21. Of note, evidence for the putative quantitative trait locus for BMI on 7p was obtained previously from such diverse populations as Mexican-Americans, Asians and Nigerians, suggesting that the underlying genes may effect weight regulation in diverse environments. An obvious positional candidate in the 7p linkage region is the gene encoding neuropepticle Y (NPY) that controls satiety and food intake.