Quantitative covariance NMR by regularization
Quantitative covariance NMR by regularization
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DOI：
10.1007/s10858-007-9148-8
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发表时间：
2007-05-01
影响因子：
2.7
通讯作者：
Brueschweiler, Rafael
中科院分区：
文献类型：
--
作者：
Chen, Yanbin;Zhang, Fengli;Brueschweiler, Rafael
协方差谱的平方根提供了沿两个维度的高谱分辨率，沿着两个维度仅需要少量的t（1）增量，其以良好的近似产生理想化的2D FT谱，前提是自旋之间交换的磁化量相对较小。当违反该条件时，2D FT和协方差峰值体积可能不同。提出了一种正则化方法，该方法产生与其2D FT类似物密切匹配的交叉峰体积的修改后的协方差谱。该方法被证明为TOCSY光谱与可变的混合时间。
The square root of a covariance spectrum, which offers high spectral resolution along both dimensions requiring only few t(1) increments, yields in good approximation the idealized 2D FT spectrum provided that the amount of magnetization exchanged between spins is relatively small. When this condition is violated, 2D FT and covariance peak volumes may differ. A regularization method is presented that produces a modified covariance spectrum with cross-peak volumes that closely match their 2D FT analogues. The method is demonstrated for TOCSY spectra with variable mixing times.