Vitrectomy in Endophthalmitis: Results of Study Using Vitrectomy, Intraocular Antibiotics, or a Combination of Both
Vitrectomy in Endophthalmitis: Results of Study Using Vitrectomy, Intraocular Antibiotics, or a Combination of Both
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眼内炎的玻璃体切除术：使用玻璃体切除术、眼内抗生素或两者联合的研究结果
DOI：
10.1001/archopht.1976.03910040738007
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发表时间：
1976
影响因子：
--
通讯作者：
R. Forster
中科院分区：
文献类型：
--
作者：
A. Cottingham;R. Forster
• A rabbit model of endophthalmitis was produced by inoculatingStaphylococcus epidermidisandS aureusinto the vitreous cavity. Elimination of microorganisms was compared using intravitreal administration of 0.1 mg of gentamicin alone, vitrectomy alone, and a combination of gentamicin and vitrectomy. In the case ofS epidermidistreated 24 hours after inoculation, all untreated eyes were culture-positive at one week, eyes treated with gentamicin alone or intravitreal gentamicin in combination with vitrectomy were all culture-negative, and vitrectomy alone rendered half of the eyes culture-negative. In the case ofS aureus, eyes not treated by vitrectomy alone were all culture-positive at one week. Eyes treated with intravitreal gentamicin 25 to 31 hours after infection were culture-negative forS aureusin 33% at one week, while eyes treated with combined vitrectomy plus intraocular gentamicin were culture-negative in 83% of cases. When treatment was delayed 40 to 49 hours after inoculation ofS aureus, intravitreal gentamicin rendered 50% culture-negative at one week, while vitrectomy combined with intravitreal gentamicin eliminated the infection in 100% of eyes.
