Mast cells in gastrointestinal disorders
Mast cells in gastrointestinal disorders
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DOI：
10.1016/j.ejphar.2016.02.018
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发表时间：
2016-05-05
影响因子：
5
通讯作者：
Bischoff, Stephan C.
中科院分区：
文献类型：
--
作者：
Bischoff, Stephan C.
肥大细胞组成性地存在于胃肠道（GI）中。据我们所知，GI肥大细胞的三种主要生理功能包括GI功能的调节，即上皮和内皮功能，与肠神经系统的串扰，以及对宿主防御细菌，病毒和寄生虫的贡献。许多慢性胃肠道疾病，包括炎症性肠病（克罗恩病、溃疡性结肠炎）、乳糜泻、肠易激综合征和食物过敏，被认为与肥大细胞增生和体液活性有关。迄今为止，以肥大细胞功能性降低为特征的临床病症尚不清楚。在本综述中，我们总结了目前的证据表明，人类肥大细胞在胃肠道屏障发挥核心作用，无论是在健康和疾病。(C)© 2016 Elsevier B.V.版权所有。
Mast cells are constitutively found in the gastrointestinal (GI) tract. The three major physiological functions of GI mast cells comprise of - as far as we know - regulation of GI functions, namely epithelial and endothelial functions, crosstalk with the enteric nervous system, and contribution to the host defense against bacterial, viral and parasitic agents. A number of chronic GI diseases, including inflammatory bowel disease (Crohn's disease, ulcerative colitis), celiac disease, irritable bowel syndrome, and food allergies, are thought to be associated with mast cell hyperplasia and humoral activity. Clinical conditions characterized by a decrease in mast cell functionality are not known so far. In the present review, we summarize current evidence which show that human mast cells play a central role at the GI barrier, both in health and disease. (C) 2016 Elsevier B.V. All rights reserved.