Activity in the lateral prefrontal cortex reflects multiple steps of future events in action plans
Activity in the lateral prefrontal cortex reflects multiple steps of future events in action plans
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DOI：
10.1016/j.neuron.2006.03.045
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发表时间：
2006-05-18
期刊：
影响因子：
16.2
通讯作者：
Tanji, Jun
中科院分区：
文献类型：
--
作者：
Mushiake, Hajime;Saito, Naohiro;Tanji, Jun
为了在复杂的环境中实现行为目标，我们必须规划运动行为的多个步骤。在计划一系列行动时，我们会预测每个行动将导致的未来事件，并在心理上组织事件的时间顺序。为了研究外侧前额叶皮层 (PFC) 在这种多步骤规划中的参与情况，我们检查了执行迷宫任务的猴子 PFC 中的神经元活动，该任务需要规划逐步光标移动才能达到目标。在准备期间，PFC 神经元反映了所有即将到来的光标运动，而不是手臂运动。相比之下，在初级运动皮层中，在准备期以及运动执行期间，大多数神经元活动反映了手臂运动，但很少反映光标运动。我们的数据表明，前额皮质主要参与规划由于行为行为而发生的多个未来事件。
To achieve a behavioral goal in a complex environment, we must plan multiple steps of motor behavior. On planning a series of actions, we anticipate future events that will occur as a result of each action and mentally organize the temporal sequence of events. To investigate the involvement of the lateral prefrontal cortex (PFC) in such multistep planning, we examined neuronal activity in the PFC of monkeys performing a maze task that required the planning of stepwise cursor movements to reach a goal. During the preparatory period, PFC neurons reflected each of all forthcoming cursor movements, rather than arm movements. In contrast, in the primary motor cortex, most neuronal activity reflected arm movements but little of cursor movements during the preparatory period, as well as during movement execution. Our data suggest that the PFC is involved primarily in planning multiple future events that occur as a consequence of behavioral actions.