Hepatic delivery of particulates in the submicron range by a hydrodynamics‐based procedure: implications for particulate gene delivery systems
Hepatic delivery of particulates in the submicron range by a hydrodynamics‐based procedure: implications for particulate gene delivery systems
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DOI：
10.1002/jgm.531
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发表时间：
2004-04
期刊：
影响因子：
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通讯作者：
Naoki Kobayashi;Kazuhiro Hirata;Shi Chen;Atsushi Kawase;M. Nishikawa;Y. Takakura
中科院分区：
文献类型：
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作者：
Naoki Kobayashi;Kazuhiro Hirata;Shi Chen;Atsushi Kawase;M. Nishikawa;Y. Takakura
大容量静脉注射DNA，即基于流体动力学的转染程序，已知是一种有效的肝脏特异性体内基因传递方法。然而，在这个过程中，很少有适用的颗粒尺寸。
A large‐volume intravenous (i.v.) injection of DNA, i.e. a hydrodynamics‐based transfection procedure, is known to be an efficient and liver‐specific method of in vivo gene delivery. However, little is available on an applicable particle size in the procedure.