Tangential migration of glutamatergic neurons and cortical patterning during development: Lessons from Cajal-Retzius cells
Tangential migration of glutamatergic neurons and cortical patterning during development: Lessons from Cajal-Retzius cells
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DOI：
10.1002/dneu.22363
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发表时间：
2016-08-01
影响因子：
3
通讯作者：
Pierani, Alessandra
中科院分区：
文献类型：
--
作者：
Barber, Melissa;Pierani, Alessandra
切向迁移是细胞运动的一种模式，在发育中的大脑皮层中，其定义为平行于脑室表面和垂直于放射状胶质纤维的位移。这种远程迁移模式是一种策略，通过这种策略，从空间和分子上不同的起源产生的不同的神经元类别可以整合在皮质板内形成适当的神经回路。虽然以前认为，只有GABA能皮质中间神经元从其在苍白球下神经节隆起中的起源切向迁移以整合在皮质板中，但现在已知GABA能神经元的瞬时群体也采用这种迁移模式。这些细胞包括Cajal-Retzius细胞（CRs）、亚板神经元（SPs）和皮层板瞬时神经元（CPTs），它们在以非细胞自主方式协调胚胎大脑皮层的径向和切向发育中起着至关重要的作用。虽然CR已被广泛研究，但仅在过去十年中，才开始阐明其切向迁移的分子机制。迄今为止，SP和CPT切向迁移的机制仍然未知。因此，我们回顾了已知的信号通路，调节CRs迁移的参数，包括他们的运动性，接触重新分配和粘附软膜表面，并讨论了这一点的背景下，如何CR迁移可能会调节其信号活性的空间和时间的方式。(c)2015年威利期刊公司开发神经生物学76：847-881，2016
Tangential migration is a mode of cell movement, which in the developing cerebral cortex, is defined by displacement parallel to the ventricular surface and orthogonal to the radial glial fibers. This mode of long-range migration is a strategy by which distinct neuronal classes generated from spatially and molecularly distinct origins can integrate to form appropriate neural circuits within the cortical plate. While it was previously believed that only GABAergic cortical interneurons migrate tangentially from their origins in the subpallial ganglionic eminences to integrate in the cortical plate, it is now known that transient populations of glutamatergic neurons also adopt this mode of migration. These include Cajal-Retzius cells (CRs), subplate neurons (SPs), and cortical plate transient neurons (CPTs), which have crucial roles in orchestrating the radial and tangential development of the embryonic cerebral cortex in a noncell-autonomous manner. While CRs have been extensively studied, it is only in the last decade that the molecular mechanisms governing their tangential migration have begun to be elucidated. To date, the mechanisms of SPs and CPTs tangential migration remain unknown. We therefore review the known signaling pathways, which regulate parameters of CRs migration including their motility, contact-redistribution and adhesion to the pial surface, and discuss this in the context of how CR migration may regulate their signaling activity in a spatial and temporal manner. (c) 2015 Wiley Periodicals, Inc. Develop Neurobiol 76: 847-881, 2016