GROWTH AND DEVELOPMENT OF HUMAN ADIPOSE-TISSUE DURING EARLY GESTATION
GROWTH AND DEVELOPMENT OF HUMAN ADIPOSE-TISSUE DURING EARLY GESTATION
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DOI：
10.1016/0378-3782(83)90028-2
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发表时间：
1983-01-01
影响因子：
2.5
通讯作者：
BOOKSTEIN, FL
中科院分区：
文献类型：
--
作者：
POISSONNET, CM;BURDI, AR;BOOKSTEIN, FL
正常年龄的人类胚胎和胎儿（805）用于研究早期产前脂肪发育。研究包括在光镜水平上观察脂肪形态发生的阶段和脂肪小叶大小和数量的计算机图像分析。选择颊脂垫作为分析的模型系统。脂肪组织在第14周和第16周之间有区别：脂肪组织形成有5个形态发生阶段，与血管的形成密切相关。脂肪小叶是在典型的空泡化脂肪细胞出现之前最早被识别的结构。关于脂肪小叶的大小和数量，在第23周之后，脂肪小叶的总数保持大致恒定，而从第23 - 29周，脂肪组织的生长主要由小叶大小的增加决定。第14 - 23周是脂肪小叶发育的敏感期，这一时期正常脂肪形成的障碍可能在以后生活中肥胖的病因学中起作用。
Normal-for-age human embryos and fetuses (805) were used to study early prenatal fat development. The investigation included observations on stages of fat morphogenesis at the light microscopic level and computerized image analyses of fat lobule size and number. The buccal fat pad was selected as a model system for the analyses. Fat tissue differentiates between the 14th and the 16th wk: there are 5 morphogenic phases in adipose tissue formation, strongly associated with the formation of blood vessels. Fat lobules are the earliest structures to be identified before typical vacuolated fat cells appear. Concerning fat lobule size and number, after the 23rd wk, the total number of fat lobules remains approximately constant, while from the 23rd-29th wk, the growth of adipose tissue is determined mainly by an increase in size of the lobules. The 14th-23rd wk is a sensitive period in fat lobule development and disturbances of normal adipogenesis during this period may play a role in the etiology of obesity in later life.